Intratumoral Radioenhancer Nanoparticle NBTXR3 Followed by Radiotherapy in Head and Neck Cancer: A Phase 1 Dose-Expansion Nonrandomized Clinical Trial.
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| Title: | Intratumoral Radioenhancer Nanoparticle NBTXR3 Followed by Radiotherapy in Head and Neck Cancer: A Phase 1 Dose-Expansion Nonrandomized Clinical Trial. |
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| Authors: | Le Tourneau C; Department of Therapeutic Innovation and Early Trials (DITEP), Institut Gustave Roussy, Villejuif, France., Liem X; Department of Radiotherapy-Brachytherapy, Oscar Lambret Cancer Center, Lille, France., Nguyen F; Department of Radiation Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Deraedt S; Departement of Head and Neck Surgery, Oscar Lambret Cancer Center, Lille, France., Salas S; Department of Medical Oncology, AMU, Assistance Publique-Hopitaux de Marseille (AP-HM), Marseille, France., Calugaru V; Department of Oncology and Radiotherapy, Institut Curie, Paris, France., Serrahima MP; Medical Oncology Department, Institut Català d'Oncologia (ICO-Hospitalet), IDIBELL, Hospitalet de Llobregat, Llobregat, Spain., Wong Hee Kam S; Department of Medical Oncology, AMU, Assistance Publique-Hopitaux de Marseille (AP-HM), Marseille, France., Hoffmann C; Department of Surgical Oncology, Institut Curie, Paris, France.; NU-MED CDiTO Tomaszow Mazowiecki, Tomaszów Mazowiecki, Poland., Lesnik M; Department of Surgical Oncology, Institut Curie, Paris, France., Blanchard P; Department of Radiation Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Poissonnet G; Department of ENT Surgery, Institut Universitaire de la Face et du Cou, Centre Antoine-Lacassagne, Université Côte d'Azur, Nice, France., Bozec A; Department of Medical Oncology, Centre Antoine Lacassagne-Institut Universitaire, Nice, France., Saada-Bouzid E; Department of Medical Oncology, Centre Antoine Lacassagne; Laboratory of Translational Research in Oncology, Cote d'Azur University, Nice, France., Jégoux F; Head and Neck Department, University Hospital, Rennes, France., Castelli J; Department of Radiotherapy, Univ Rennes, CLCC Eugène Marquis, INSERM, LTSI-UMR, Rennes, France., Devisetty K; Johnson & Johnson, New Brunswick, New Jersey., Lelonge Y; ENT-Head and Neck Surgery Service, Saint-Étienne University Hospital Center, Saint-Priest-en-Jarez, France., Jadaud E; Radiation Department, Saint-Étienne University Hospital Center, Saint-Priest-en-Jarez, France., Houdas L; Nanobiotix, SA, Paris, France., Debard A; Nanobiotix, SA, Paris, France., Vivar OI; Nanobiotix, SA, Paris, France., Finzi L; Nanobiotix, SA, Paris, France., Serra A; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.; Department of Statistical Methodology, Saryga, Tournus, France., Linares I; Department of Radiation Oncology, Institut Català d'Oncologia (ICO), Radiobiology and Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Arranz Obispo C; Department of Maxillofacial and Oral Surgery, Bellvitge University Hospital (HUB), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Thariat J; Department of Radiation Oncology, François Baclesse Center, Caen, France., Rambeau A; Department of Medical Oncology, UCP VADS, Centre François Baclesse, Caen, France., Fakhry N; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, Marseille, France., Santini L; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, Marseille, France., Giralt J; Department of Radiation Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Braña García I; Department of Medical Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Barba MS; Maxillofacial Surgery Service, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Gorphe P; Department of Head and Neck Oncology, Institute Gustave Roussy, Université Paris-Saclay, Villejuif, France., Helfferich F; Medical Center, Hungarian Defense Forces, Budapest, Hungary., Herczeg A; Center of Radiotherapy and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary., Papai Z; Medical Center, Hungarian Defense Forces, Budapest, Hungary., Fijuth J; Departement of Head and Neck Surgery, Oscar Lambret Cancer Center, Lille, France., Takácsi-Nagy Z; Center of Radiotherapy and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.; Department of Oncology, Semmelweis University, Budapest, Hungary. |
| Source: | JAMA otolaryngology-- head & neck surgery [JAMA Otolaryngol Head Neck Surg] 2026 Mar 01; Vol. 152 (3), pp. 284-293. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Multicenter Study |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589542 Publication Model: Print Cited Medium: Internet ISSN: 2168-619X (Electronic) Linking ISSN: 21686181 NLM ISO Abbreviation: JAMA Otolaryngol Head Neck Surg Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2168-619X |
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| DOI: | 10.1001/jamaoto.2025.4939 |
