View in EDS HTML Full Text PDF Full Text

Intratumoral Radioenhancer Nanoparticle NBTXR3 Followed by Radiotherapy in Head and Neck Cancer: A Phase 1 Dose-Expansion Nonrandomized Clinical Trial.

Saved in:
Bibliographic Details
Title: Intratumoral Radioenhancer Nanoparticle NBTXR3 Followed by Radiotherapy in Head and Neck Cancer: A Phase 1 Dose-Expansion Nonrandomized Clinical Trial.
Authors: Le Tourneau C; Department of Therapeutic Innovation and Early Trials (DITEP), Institut Gustave Roussy, Villejuif, France., Liem X; Department of Radiotherapy-Brachytherapy, Oscar Lambret Cancer Center, Lille, France., Nguyen F; Department of Radiation Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Deraedt S; Departement of Head and Neck Surgery, Oscar Lambret Cancer Center, Lille, France., Salas S; Department of Medical Oncology, AMU, Assistance Publique-Hopitaux de Marseille (AP-HM), Marseille, France., Calugaru V; Department of Oncology and Radiotherapy, Institut Curie, Paris, France., Serrahima MP; Medical Oncology Department, Institut Català d'Oncologia (ICO-Hospitalet), IDIBELL, Hospitalet de Llobregat, Llobregat, Spain., Wong Hee Kam S; Department of Medical Oncology, AMU, Assistance Publique-Hopitaux de Marseille (AP-HM), Marseille, France., Hoffmann C; Department of Surgical Oncology, Institut Curie, Paris, France.; NU-MED CDiTO Tomaszow Mazowiecki, Tomaszów Mazowiecki, Poland., Lesnik M; Department of Surgical Oncology, Institut Curie, Paris, France., Blanchard P; Department of Radiation Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Poissonnet G; Department of ENT Surgery, Institut Universitaire de la Face et du Cou, Centre Antoine-Lacassagne, Université Côte d'Azur, Nice, France., Bozec A; Department of Medical Oncology, Centre Antoine Lacassagne-Institut Universitaire, Nice, France., Saada-Bouzid E; Department of Medical Oncology, Centre Antoine Lacassagne; Laboratory of Translational Research in Oncology, Cote d'Azur University, Nice, France., Jégoux F; Head and Neck Department, University Hospital, Rennes, France., Castelli J; Department of Radiotherapy, Univ Rennes, CLCC Eugène Marquis, INSERM, LTSI-UMR, Rennes, France., Devisetty K; Johnson & Johnson, New Brunswick, New Jersey., Lelonge Y; ENT-Head and Neck Surgery Service, Saint-Étienne University Hospital Center, Saint-Priest-en-Jarez, France., Jadaud E; Radiation Department, Saint-Étienne University Hospital Center, Saint-Priest-en-Jarez, France., Houdas L; Nanobiotix, SA, Paris, France., Debard A; Nanobiotix, SA, Paris, France., Vivar OI; Nanobiotix, SA, Paris, France., Finzi L; Nanobiotix, SA, Paris, France., Serra A; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.; Department of Statistical Methodology, Saryga, Tournus, France., Linares I; Department of Radiation Oncology, Institut Català d'Oncologia (ICO), Radiobiology and Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Arranz Obispo C; Department of Maxillofacial and Oral Surgery, Bellvitge University Hospital (HUB), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Thariat J; Department of Radiation Oncology, François Baclesse Center, Caen, France., Rambeau A; Department of Medical Oncology, UCP VADS, Centre François Baclesse, Caen, France., Fakhry N; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, Marseille, France., Santini L; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, Marseille, France., Giralt J; Department of Radiation Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Braña García I; Department of Medical Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Barba MS; Maxillofacial Surgery Service, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Gorphe P; Department of Head and Neck Oncology, Institute Gustave Roussy, Université Paris-Saclay, Villejuif, France., Helfferich F; Medical Center, Hungarian Defense Forces, Budapest, Hungary., Herczeg A; Center of Radiotherapy and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary., Papai Z; Medical Center, Hungarian Defense Forces, Budapest, Hungary., Fijuth J; Departement of Head and Neck Surgery, Oscar Lambret Cancer Center, Lille, France., Takácsi-Nagy Z; Center of Radiotherapy and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.; Department of Oncology, Semmelweis University, Budapest, Hungary.
Source: JAMA otolaryngology-- head & neck surgery [JAMA Otolaryngol Head Neck Surg] 2026 Mar 01; Vol. 152 (3), pp. 284-293.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589542 Publication Model: Print Cited Medium: Internet ISSN: 2168-619X (Electronic) Linking ISSN: 21686181 NLM ISO Abbreviation: JAMA Otolaryngol Head Neck Surg Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41609775
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Intratumoral Radioenhancer Nanoparticle NBTXR3 Followed by Radiotherapy in Head and Neck Cancer: A Phase 1 Dose-Expansion Nonrandomized Clinical Trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Le+Tourneau+C%22">Le Tourneau C</searchLink>; Department of Therapeutic Innovation and Early Trials (DITEP), Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Liem+X%22">Liem X</searchLink>; Department of Radiotherapy-Brachytherapy, Oscar Lambret Cancer Center, Lille, France.<br /><searchLink fieldCode="AU" term="%22Nguyen+F%22">Nguyen F</searchLink>; Department of Radiation Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Deraedt+S%22">Deraedt S</searchLink>; Departement of Head and Neck Surgery, Oscar Lambret Cancer Center, Lille, France.<br /><searchLink fieldCode="AU" term="%22Salas+S%22">Salas S</searchLink>; Department of Medical Oncology, AMU, Assistance Publique-Hopitaux de Marseille (AP-HM), Marseille, France.<br /><searchLink fieldCode="AU" term="%22Calugaru+V%22">Calugaru V</searchLink>; Department of Oncology and Radiotherapy, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Serrahima+MP%22">Serrahima MP</searchLink>; Medical Oncology Department, Institut Català d'Oncologia (ICO-Hospitalet), IDIBELL, Hospitalet de Llobregat, Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Wong+Hee+Kam+S%22">Wong Hee Kam S</searchLink>; Department of Medical Oncology, AMU, Assistance Publique-Hopitaux de Marseille (AP-HM), Marseille, France.<br /><searchLink fieldCode="AU" term="%22Hoffmann+C%22">Hoffmann C</searchLink>; Department of Surgical Oncology, Institut Curie, Paris, France.; NU-MED CDiTO Tomaszow Mazowiecki, Tomaszów Mazowiecki, Poland.<br /><searchLink fieldCode="AU" term="%22Lesnik+M%22">Lesnik M</searchLink>; Department of Surgical Oncology, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Blanchard+P%22">Blanchard P</searchLink>; Department of Radiation Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Poissonnet+G%22">Poissonnet G</searchLink>; Department of ENT Surgery, Institut Universitaire de la Face et du Cou, Centre Antoine-Lacassagne, Université Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bozec+A%22">Bozec A</searchLink>; Department of Medical Oncology, Centre Antoine Lacassagne-Institut Universitaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Saada-Bouzid+E%22">Saada-Bouzid E</searchLink>; Department of Medical Oncology, Centre Antoine Lacassagne; Laboratory of Translational Research in Oncology, Cote d'Azur University, Nice, France.<br /><searchLink fieldCode="AU" term="%22Jégoux+F%22">Jégoux F</searchLink>; Head and Neck Department, University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Castelli+J%22">Castelli J</searchLink>; Department of Radiotherapy, Univ Rennes, CLCC Eugène Marquis, INSERM, LTSI-UMR, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Devisetty+K%22">Devisetty K</searchLink>; Johnson & Johnson, New Brunswick, New Jersey.<br /><searchLink fieldCode="AU" term="%22Lelonge+Y%22">Lelonge Y</searchLink>; ENT-Head and Neck Surgery Service, Saint-Étienne University Hospital Center, Saint-Priest-en-Jarez, France.<br /><searchLink fieldCode="AU" term="%22Jadaud+E%22">Jadaud E</searchLink>; Radiation Department, Saint-Étienne University Hospital Center, Saint-Priest-en-Jarez, France.<br /><searchLink fieldCode="AU" term="%22Houdas+L%22">Houdas L</searchLink>; Nanobiotix, SA, Paris, France.<br /><searchLink fieldCode="AU" term="%22Debard+A%22">Debard A</searchLink>; Nanobiotix, SA, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vivar+OI%22">Vivar OI</searchLink>; Nanobiotix, SA, Paris, France.<br /><searchLink fieldCode="AU" term="%22Finzi+L%22">Finzi L</searchLink>; Nanobiotix, SA, Paris, France.<br /><searchLink fieldCode="AU" term="%22Serra+A%22">Serra A</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.; Department of Statistical Methodology, Saryga, Tournus, France.<br /><searchLink fieldCode="AU" term="%22Linares+I%22">Linares I</searchLink>; Department of Radiation Oncology, Institut Català d'Oncologia (ICO), Radiobiology and Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arranz+Obispo+C%22">Arranz Obispo C</searchLink>; Department of Maxillofacial and Oral Surgery, Bellvitge University Hospital (HUB), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Thariat+J%22">Thariat J</searchLink>; Department of Radiation Oncology, François Baclesse Center, Caen, France.<br /><searchLink fieldCode="AU" term="%22Rambeau+A%22">Rambeau A</searchLink>; Department of Medical Oncology, UCP VADS, Centre François Baclesse, Caen, France.<br /><searchLink fieldCode="AU" term="%22Fakhry+N%22">Fakhry N</searchLink>; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Santini+L%22">Santini L</searchLink>; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Giralt+J%22">Giralt J</searchLink>; Department of Radiation Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Braña+García+I%22">Braña García I</searchLink>; Department of Medical Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Barba+MS%22">Barba MS</searchLink>; Maxillofacial Surgery Service, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gorphe+P%22">Gorphe P</searchLink>; Department of Head and Neck Oncology, Institute Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Helfferich+F%22">Helfferich F</searchLink>; Medical Center, Hungarian Defense Forces, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Herczeg+A%22">Herczeg A</searchLink>; Center of Radiotherapy and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Papai+Z%22">Papai Z</searchLink>; Medical Center, Hungarian Defense Forces, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Fijuth+J%22">Fijuth J</searchLink>; Departement of Head and Neck Surgery, Oscar Lambret Cancer Center, Lille, France.<br /><searchLink fieldCode="AU" term="%22Takácsi-Nagy+Z%22">Takácsi-Nagy Z</searchLink>; Center of Radiotherapy and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.; Department of Oncology, Semmelweis University, Budapest, Hungary.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101589542%22">JAMA otolaryngology-- head & neck surgery</searchLink> [JAMA Otolaryngol Head Neck Surg] 2026 Mar 01; Vol. 152 (3), pp. 284-293.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase I; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589542 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2168-619X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221686181%22">21686181 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Otolaryngol Head Neck Surg <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41609775
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1001/jamaoto.2025.4939
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 284
    Titles:
      – TitleFull: Intratumoral Radioenhancer Nanoparticle NBTXR3 Followed by Radiotherapy in Head and Neck Cancer: A Phase 1 Dose-Expansion Nonrandomized Clinical Trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Le Tourneau C
      – PersonEntity:
          Name:
            NameFull: Liem X
      – PersonEntity:
          Name:
            NameFull: Nguyen F
      – PersonEntity:
          Name:
            NameFull: Deraedt S
      – PersonEntity:
          Name:
            NameFull: Salas S
      – PersonEntity:
          Name:
            NameFull: Calugaru V
      – PersonEntity:
          Name:
            NameFull: Serrahima MP
      – PersonEntity:
          Name:
            NameFull: Wong Hee Kam S
      – PersonEntity:
          Name:
            NameFull: Hoffmann C
      – PersonEntity:
          Name:
            NameFull: Lesnik M
      – PersonEntity:
          Name:
            NameFull: Blanchard P
      – PersonEntity:
          Name:
            NameFull: Poissonnet G
      – PersonEntity:
          Name:
            NameFull: Bozec A
      – PersonEntity:
          Name:
            NameFull: Saada-Bouzid E
      – PersonEntity:
          Name:
            NameFull: Jégoux F
      – PersonEntity:
          Name:
            NameFull: Castelli J
      – PersonEntity:
          Name:
            NameFull: Devisetty K
      – PersonEntity:
          Name:
            NameFull: Lelonge Y
      – PersonEntity:
          Name:
            NameFull: Jadaud E
      – PersonEntity:
          Name:
            NameFull: Houdas L
      – PersonEntity:
          Name:
            NameFull: Debard A
      – PersonEntity:
          Name:
            NameFull: Vivar OI
      – PersonEntity:
          Name:
            NameFull: Finzi L
      – PersonEntity:
          Name:
            NameFull: Serra A
      – PersonEntity:
          Name:
            NameFull: Linares I
      – PersonEntity:
          Name:
            NameFull: Arranz Obispo C
      – PersonEntity:
          Name:
            NameFull: Thariat J
      – PersonEntity:
          Name:
            NameFull: Rambeau A
      – PersonEntity:
          Name:
            NameFull: Fakhry N
      – PersonEntity:
          Name:
            NameFull: Santini L
      – PersonEntity:
          Name:
            NameFull: Giralt J
      – PersonEntity:
          Name:
            NameFull: Braña García I
      – PersonEntity:
          Name:
            NameFull: Barba MS
      – PersonEntity:
          Name:
            NameFull: Gorphe P
      – PersonEntity:
          Name:
            NameFull: Helfferich F
      – PersonEntity:
          Name:
            NameFull: Herczeg A
      – PersonEntity:
          Name:
            NameFull: Papai Z
      – PersonEntity:
          Name:
            NameFull: Fijuth J
      – PersonEntity:
          Name:
            NameFull: Takácsi-Nagy Z
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2168-619X
          Numbering:
            – Type: volume
              Value: 152
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: JAMA otolaryngology-- head & neck surgery
              Type: main
ResultId 1