Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial.
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| Title: | Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial. |
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| Authors: | Bernholm KF; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Johansen ND; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Espersen C; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Modin D; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Hyldekær KJ; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Nealon J; Sanofi, Lyon, France., Samson S; Sanofi, Lyon, France., Loiacono MM; Sanofi, PA, Swiftwater, USA., Harris RC; Sanofi, Singapore., Larsen CS; Department of Clinical Medicine, Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Jensen AMR; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Landler NE; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Nielsen ST; Department of Intensive Care, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Russell L; Department of Intensive Care, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Itenov TS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Claggett BL; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Solomon SD; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Landray MJ; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Gislason GH; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Heart Foundation, Copenhagen, Denmark.; The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Køber L; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet , Copenhagen, Denmark., Sivapalan P; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Respiratory Research, Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Jensen JUS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Respiratory Research, Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Biering-Sørensen T; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. tor.biering@gmail.com.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. tor.biering@gmail.com.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark. tor.biering@gmail.com. |
| Source: | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2026 May; Vol. 45 (5), pp. 1323-1332. Date of Electronic Publication: 2026 Jan 29. |
| Publication Type: | Journal Article; Pragmatic Clinical Trial; Randomized Controlled Trial |
| Journal Info: | Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41609947 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bernholm+KF%22">Bernholm KF</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Johansen+ND%22">Johansen ND</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Espersen+C%22">Espersen C</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Modin+D%22">Modin D</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hyldekær+KJ%22">Hyldekær KJ</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nealon+J%22">Nealon J</searchLink>; Sanofi, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Samson+S%22">Samson S</searchLink>; Sanofi, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Loiacono+MM%22">Loiacono MM</searchLink>; Sanofi, PA, Swiftwater, USA.<br /><searchLink fieldCode="AU" term="%22Harris+RC%22">Harris RC</searchLink>; Sanofi, Singapore.<br /><searchLink fieldCode="AU" term="%22Larsen+CS%22">Larsen CS</searchLink>; Department of Clinical Medicine, Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+AMR%22">Jensen AMR</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Landler+NE%22">Landler NE</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+ST%22">Nielsen ST</searchLink>; Department of Intensive Care, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Russell+L%22">Russell L</searchLink>; Department of Intensive Care, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Itenov+TS%22">Itenov TS</searchLink>; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Claggett+BL%22">Claggett BL</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Solomon+SD%22">Solomon SD</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Landray+MJ%22">Landray MJ</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gislason+GH%22">Gislason GH</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Heart Foundation, Copenhagen, Denmark.; The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Køber+L%22">Køber L</searchLink>; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet , Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sivapalan+P%22">Sivapalan P</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Respiratory Research, Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+JUS%22">Jensen JUS</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Respiratory Research, Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Biering-Sørensen+T%22">Biering-Sørensen T</searchLink>; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. tor.biering@gmail.com.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. tor.biering@gmail.com.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark. tor.biering@gmail.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228804297%22">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</searchLink> [Eur J Clin Microbiol Infect Dis] 2026 May; Vol. 45 (5), pp. 1323-1332. <i>Date of Electronic Publication: </i>2026 Jan 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Pragmatic Clinical Trial; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8804297 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-4373 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209349723%22">09349723 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Clin Microbiol Infect Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41609947 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10096-026-05408-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1323 Titles: – TitleFull: Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bernholm KF – PersonEntity: Name: NameFull: Johansen ND – PersonEntity: Name: NameFull: Espersen C – PersonEntity: Name: NameFull: Modin D – PersonEntity: Name: NameFull: Hyldekær KJ – PersonEntity: Name: NameFull: Nealon J – PersonEntity: Name: NameFull: Samson S – PersonEntity: Name: NameFull: Loiacono MM – PersonEntity: Name: NameFull: Harris RC – PersonEntity: Name: NameFull: Larsen CS – PersonEntity: Name: NameFull: Jensen AMR – PersonEntity: Name: NameFull: Landler NE – PersonEntity: Name: NameFull: Nielsen ST – PersonEntity: Name: NameFull: Russell L – PersonEntity: Name: NameFull: Itenov TS – PersonEntity: Name: NameFull: Claggett BL – PersonEntity: Name: NameFull: Solomon SD – PersonEntity: Name: NameFull: Landray MJ – PersonEntity: Name: NameFull: Gislason GH – PersonEntity: Name: NameFull: Køber L – PersonEntity: Name: NameFull: Sivapalan P – PersonEntity: Name: NameFull: Jensen JUS – PersonEntity: Name: NameFull: Biering-Sørensen T IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1435-4373 Numbering: – Type: volume Value: 45 – Type: issue Value: 5 Titles: – TitleFull: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Type: main |
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