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A Validated LC-MS/MS Method for Unbound Rifapentine Quantitation Reveals Nonlinear Plasma Protein Binding and Comparable Free Fractions Between Adults and Children with Tuberculosis.

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Title: A Validated LC-MS/MS Method for Unbound Rifapentine Quantitation Reveals Nonlinear Plasma Protein Binding and Comparable Free Fractions Between Adults and Children with Tuberculosis.
Authors: Qiao W; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China., Fang M; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China., Liu M; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China., He T; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China., Zhang P; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China. 82880246@qq.com.; Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China. 82880246@qq.com., Li W; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China. yaojike-01@szsy.sustech.edu.cn.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China. yaojike-01@szsy.sustech.edu.cn.
Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2026 Mar; Vol. 51 (2), pp. 157-168. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2107-0180 (Electronic) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Qiao+W%22">Qiao W</searchLink>; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Fang+M%22">Fang M</searchLink>; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22He+T%22">He T</searchLink>; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China. 82880246@qq.com.; Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China. 82880246@qq.com.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, Guangdong, 518112, People's Republic of China. yaojike-01@szsy.sustech.edu.cn.; Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Diseases, Shenzhen, 518112, Guangdong, People's Republic of China. yaojike-01@szsy.sustech.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%227608491%22">European journal of drug metabolism and pharmacokinetics</searchLink> [Eur J Drug Metab Pharmacokinet] 2026 Mar; Vol. 51 (2), pp. 157-168. <i>Date of Electronic Publication: </i>2026 Jan 29.
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              Text: 2026 Mar
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