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Engineered aldehyde dehydrogenases for amide bond formation.

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Title: Engineered aldehyde dehydrogenases for amide bond formation.
Authors: Gao L; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China., Qiu X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China., Yang J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Hu K; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China., Li P; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China., Li W; Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, China., Gao F; Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, China., Gallou F; Chemical and Analytical Development, Novartis Pharma AG, Novartis Campus, Basel, Switzerland., Kleinbeck F; Chemical and Analytical Development, Novartis Pharma AG, Novartis Campus, Basel, Switzerland., Lei X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Source: Science (New York, N.Y.) [Science] 2026 Jan 29; Vol. 391 (6784), pp. eadw3365. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered aldehyde dehydrogenases for amide bond formation.
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  Data: <searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Qiu+X%22">Qiu X</searchLink>; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hu+K%22">Hu K</searchLink>; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, China.<br /><searchLink fieldCode="AU" term="%22Gao+F%22">Gao F</searchLink>; Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, China.<br /><searchLink fieldCode="AU" term="%22Gallou+F%22">Gallou F</searchLink>; Chemical and Analytical Development, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kleinbeck+F%22">Kleinbeck F</searchLink>; Chemical and Analytical Development, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lei+X%22">Lei X</searchLink>; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jan 29; Vol. 391 (6784), pp. eadw3365. <i>Date of Electronic Publication: </i>2026 Jan 29.
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              Text: 2026 Jan 29
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