DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.
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| Title: | DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality. |
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| Authors: | Tomaskovic I; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Prieto-Garcia C; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Boskovic M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia., Glumac M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia., Tsai TL; Institute of Molecular Biology (IMB), Mainz, Germany., Mosler T; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biology (IMB), Mainz, Germany., Kazi R; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Rathore R; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Andrade J; Angiogenesis & Metabolism Laboratory, Center of Vascular Biomedicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Hoffmann M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Giuliani G; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Jacomin AC; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Pereira RS; Georg-Speyer-Haus Institute for Tumor Biology and Experimental Medicine and Goethe University Frankfurt, Frankfurt, Germany., Knop E; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Wachsmuth L; Institute for Genetics, University of Cologne, Cologne, Germany., Beli P; Institute of Molecular Biology (IMB), Mainz, Germany., Husnjak K; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Pasparakis M; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Germany. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Ablasser A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland., Krause DS; Institute of Transfusion Medicine, Transfusion Center, University Medicine Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, Mainz, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Germany., Potente M; Angiogenesis & Metabolism Laboratory, Center of Vascular Biomedicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Papathanasiou S; Institute of Molecular Biology (IMB), Mainz, Germany., Terzic J; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia., Dikic I; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany. |
| Source: | Science (New York, N.Y.) [Science] 2026 Jan 29; Vol. 391 (6784), pp. eadx9445. Date of Electronic Publication: 2026 Jan 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adx9445 |
