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DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.

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Title: DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.
Authors: Tomaskovic I; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Prieto-Garcia C; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Boskovic M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia., Glumac M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia., Tsai TL; Institute of Molecular Biology (IMB), Mainz, Germany., Mosler T; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biology (IMB), Mainz, Germany., Kazi R; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Rathore R; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Andrade J; Angiogenesis & Metabolism Laboratory, Center of Vascular Biomedicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Hoffmann M; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Giuliani G; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Jacomin AC; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Pereira RS; Georg-Speyer-Haus Institute for Tumor Biology and Experimental Medicine and Goethe University Frankfurt, Frankfurt, Germany., Knop E; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Wachsmuth L; Institute for Genetics, University of Cologne, Cologne, Germany., Beli P; Institute of Molecular Biology (IMB), Mainz, Germany., Husnjak K; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany., Pasparakis M; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Germany. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Ablasser A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland., Krause DS; Institute of Transfusion Medicine, Transfusion Center, University Medicine Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, Mainz, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Germany., Potente M; Angiogenesis & Metabolism Laboratory, Center of Vascular Biomedicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Papathanasiou S; Institute of Molecular Biology (IMB), Mainz, Germany., Terzic J; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia., Dikic I; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.
Source: Science (New York, N.Y.) [Science] 2026 Jan 29; Vol. 391 (6784), pp. eadx9445. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.
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  Data: <searchLink fieldCode="AU" term="%22Tomaskovic+I%22">Tomaskovic I</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Prieto-Garcia+C%22">Prieto-Garcia C</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Boskovic+M%22">Boskovic M</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Glumac+M%22">Glumac M</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Tsai+TL%22">Tsai TL</searchLink>; Institute of Molecular Biology (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Mosler+T%22">Mosler T</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Molecular Biology (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kazi+R%22">Kazi R</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Rathore+R%22">Rathore R</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Andrade+J%22">Andrade J</searchLink>; Angiogenesis & Metabolism Laboratory, Center of Vascular Biomedicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+M%22">Hoffmann M</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Giuliani+G%22">Giuliani G</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Jacomin+AC%22">Jacomin AC</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Pereira+RS%22">Pereira RS</searchLink>; Georg-Speyer-Haus Institute for Tumor Biology and Experimental Medicine and Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Knop+E%22">Knop E</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wachsmuth+L%22">Wachsmuth L</searchLink>; Institute for Genetics, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Beli+P%22">Beli P</searchLink>; Institute of Molecular Biology (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Husnjak+K%22">Husnjak K</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Pasparakis+M%22">Pasparakis M</searchLink>; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Germany. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ablasser+A%22">Ablasser A</searchLink>; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Krause+DS%22">Krause DS</searchLink>; Institute of Transfusion Medicine, Transfusion Center, University Medicine Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, Mainz, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Germany.<br /><searchLink fieldCode="AU" term="%22Potente+M%22">Potente M</searchLink>; Angiogenesis & Metabolism Laboratory, Center of Vascular Biomedicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Papathanasiou+S%22">Papathanasiou S</searchLink>; Institute of Molecular Biology (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Terzic+J%22">Terzic J</searchLink>; Laboratory for Cancer Research, University of Split School of Medicine, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Dikic+I%22">Dikic I</searchLink>; Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jan 29; Vol. 391 (6784), pp. eadx9445. <i>Date of Electronic Publication: </i>2026 Jan 29.
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