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IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.

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Title: IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.
Authors: Denz PJ; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., Speaks S; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., McFadden MI; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., Cable JM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., Aladhami AK; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA., Papa JL; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., Rayner RE; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA., Rao PR; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA., Leumi S; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., Roettger JE; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA., Dhariwala MO; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Department of Dermatology, The Ohio State University, Columbus, OH, USA., Cormet-Boyaka E; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA., Forero A; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Adriana.Forero@osumc.edu.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA. Adriana.Forero@osumc.edu., Yount JS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Jacob.Yount@osumc.edu.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA. Jacob.Yount@osumc.edu.
Source: Nature communications [Nat Commun] 2026 Jan 29; Vol. 17 (1), pp. 1779. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Denz+PJ%22">Denz PJ</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Speaks+S%22">Speaks S</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22McFadden+MI%22">McFadden MI</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cable+JM%22">Cable JM</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Aladhami+AK%22">Aladhami AK</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Papa+JL%22">Papa JL</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rayner+RE%22">Rayner RE</searchLink>; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rao+PR%22">Rao PR</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Leumi+S%22">Leumi S</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Roettger+JE%22">Roettger JE</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dhariwala+MO%22">Dhariwala MO</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.; Department of Dermatology, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cormet-Boyaka+E%22">Cormet-Boyaka E</searchLink>; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Forero+A%22">Forero A</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Adriana.Forero@osumc.edu.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA. Adriana.Forero@osumc.edu.<br /><searchLink fieldCode="AU" term="%22Yount+JS%22">Yount JS</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Jacob.Yount@osumc.edu.; Virsues and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA. Jacob.Yount@osumc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 29; Vol. 17 (1), pp. 1779. <i>Date of Electronic Publication: </i>2026 Jan 29.
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