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Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels.

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Title: Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels.
Authors: Dong P; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201801, China., Fan QK; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Ke SX; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310007, China., Wang JQ; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Mei Y; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Ding YT; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Wang J; Department of Pathology, Yaan People's Hospital (Yaan Hospital of West China Hospital of Sichuan University), Ya-an, 625000, China., Xu J; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Zhou N; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Xu YY; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Wang JJ; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Chen C; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Wang XH; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China., Cui M; Department of Pharmaceutical Sciences and the Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, 02115, MA, USA., Du YM; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yimeidu@mail.hust.edu.cn., Sokabe M; Mechanobiology Laboratory, Nagoya University, Graduate School of Medicine, Nagoya, 464-8601, Japan. msokabe@med.nagoya-u.ac.jp.; Human Information Systems Lab, Kanazawa Institute of Technology, Hakusan, 924-0838, Japan. msokabe@med.nagoya-u.ac.jp., Tang MX; Department of Pathology, Yaan People's Hospital (Yaan Hospital of West China Hospital of Sichuan University), Ya-an, 625000, China. mxtang69@163.com., Zhang Z; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. Zhangzhe70@xzhmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China. Zhangzhe70@xzhmu.edu.cn., Tang QY; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. qiongyaotang@xzhmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China. qiongyaotang@xzhmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1436-1453. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels.
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  Data: <searchLink fieldCode="AU" term="%22Dong+P%22">Dong P</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201801, China.<br /><searchLink fieldCode="AU" term="%22Fan+QK%22">Fan QK</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Ke+SX%22">Ke SX</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Wang+JQ%22">Wang JQ</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Mei+Y%22">Mei Y</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Ding+YT%22">Ding YT</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Pathology, Yaan People's Hospital (Yaan Hospital of West China Hospital of Sichuan University), Ya-an, 625000, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Zhou+N%22">Zhou N</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Xu+YY%22">Xu YY</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wang+JJ%22">Wang JJ</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wang+XH%22">Wang XH</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Cui+M%22">Cui M</searchLink>; Department of Pharmaceutical Sciences and the Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, 02115, MA, USA.<br /><searchLink fieldCode="AU" term="%22Du+YM%22">Du YM</searchLink>; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yimeidu@mail.hust.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sokabe+M%22">Sokabe M</searchLink>; Mechanobiology Laboratory, Nagoya University, Graduate School of Medicine, Nagoya, 464-8601, Japan. msokabe@med.nagoya-u.ac.jp.; Human Information Systems Lab, Kanazawa Institute of Technology, Hakusan, 924-0838, Japan. msokabe@med.nagoya-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Tang+MX%22">Tang MX</searchLink>; Department of Pathology, Yaan People's Hospital (Yaan Hospital of West China Hospital of Sichuan University), Ya-an, 625000, China. mxtang69@163.com.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. Zhangzhe70@xzhmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China. Zhangzhe70@xzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+QY%22">Tang QY</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. qiongyaotang@xzhmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China. qiongyaotang@xzhmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1436-1453. <i>Date of Electronic Publication: </i>2026 Jan 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-025-01698-1
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              Text: 2026 Jun
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