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Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium.

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Title: Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium.
Authors: Farncombe KM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Sobotka JA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Aronson M; Zane Cohen Centre for Digestive Diseases, Sinai Health, Toronto, ON, Canada., Basik M; Department of Surgery, McGill University Medical School, Montreal, QC, Canada.; Department of Oncology, McGill University Medical School, Montreal, QC, Canada., Bombard Y; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada., Born L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Cheifetz R; BC Cancer, Vancouver, BC, Canada., Clausen M; Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada., Coburn N; ICES, Toronto, ON, Canada.; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada., Dawson L; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada., Doria AS; Department of Diagnostic & Interventional Radiology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada., Elbanna KY; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada., Etchegary H; NLSUPPORT, Memorial University of Newfoundland, St. John's, NL, Canada.; Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Foulkes WD; Department of Human Genetics, McGill University, Montreal, QC, Canada., Hessels C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hyde A; Dr. H. Bliss Murphy Cancer Center, St. John's, NL, Canada., Kazazian K; Department of Surgery, University of Toronto, Toronto, ON, Canada.; Department of Surgical Oncology, Toronto General Hospital, University Health Network, Toronto, ON, Canada., Kinnaird A; Department of Surgery, University of Alberta, Edmonton, AB, Canada., Koch CA; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada., Laframboise S; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada.; Division of Gynecology Oncology, University Health Network, Sinai Health System, Toronto, ON, Canada., Lerner-Ellis J; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada., Lheureux S; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network/Sinai Health System, Toronto, ON, Canada.; Department of Medical Oncology and Hematology, University of Toronto, Toronto, ON, Canada., Malkin D; Division of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Metser U; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.; University Medical Imaging Toronto, Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, Women's College Hospital, Toronto, ON, Canada., Penney LS; Dalhousie University, Halifax, NS, Canada., Ridd S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Schrader KA; BC Cancer, Vancouver, BC, Canada.; University of British Columbia, Vancouver, BC, Canada., Tiano T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Tone AA; Ovarian Cancer Canada, Toronto, ON, Canada., Veit-Haibach P; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Wong S; The Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada., Xu W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Trevor.Pugh@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Trevor.Pugh@utoronto.ca.; Ontario Institute for Cancer Research, Toronto, ON, Canada. Trevor.Pugh@utoronto.ca., Kim RH; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network/Sinai Health System, Toronto, ON, Canada. Raymond.Kim@uhn.ca.; Ontario Institute for Cancer Research, Toronto, ON, Canada. Raymond.Kim@uhn.ca.; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada. Raymond.Kim@uhn.ca.; Department of Medicine, University of Toronto, Toronto, ON, Canada. Raymond.Kim@uhn.ca.
Source: European journal of human genetics : EJHG [Eur J Hum Genet] 2026 Jan 29. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium.
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Bliss Murphy Cancer Center, St. John's, NL, Canada.<br /><searchLink fieldCode="AU" term="%22Kazazian+K%22">Kazazian K</searchLink>; Department of Surgery, University of Toronto, Toronto, ON, Canada.; Department of Surgical Oncology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kinnaird+A%22">Kinnaird A</searchLink>; Department of Surgery, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Koch+CA%22">Koch CA</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Laframboise+S%22">Laframboise S</searchLink>; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada.; Division of Gynecology Oncology, University Health Network, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lerner-Ellis+J%22">Lerner-Ellis J</searchLink>; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lheureux+S%22">Lheureux S</searchLink>; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network/Sinai Health System, Toronto, ON, Canada.; Department of Medical Oncology and Hematology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Malkin+D%22">Malkin D</searchLink>; Division of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Metser+U%22">Metser U</searchLink>; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.; University Medical Imaging Toronto, Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, Women's College Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Penney+LS%22">Penney LS</searchLink>; Dalhousie University, Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Ridd+S%22">Ridd S</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Schrader+KA%22">Schrader KA</searchLink>; BC Cancer, Vancouver, BC, Canada.; University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Tiano+T%22">Tiano T</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tone+AA%22">Tone AA</searchLink>; Ovarian Cancer Canada, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Veit-Haibach+P%22">Veit-Haibach P</searchLink>; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+S%22">Wong S</searchLink>; The Sir Mortimer B. 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Raymond.Kim@uhn.ca.; Department of Medicine, University of Toronto, Toronto, ON, Canada. Raymond.Kim@uhn.ca.
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