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Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization.

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Title: Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization.
Authors: Ausserwöger H; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Scrutton R; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Fischer CM; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Sneideris T; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Qian D; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., de Csilléry E; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Baronaite I; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Saar KL; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Białek AZ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Oeller M; Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Krainer G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Biophysics, Institute of Molecular Biosciences (IMB), NAWI Graz, University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria.; Field of Excellence BioHealth, University of Graz, Graz, Austria., Franzmann TM; Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany., Wittmann S; Institute of Molecular Biology (IMB), Mainz, Germany., Iglesias-Artola JM; Max Planck Institute of Cell Biology and Genetics (MPI-CBG), Dresden, Germany., Invernizzi G; Therapeutics Discovery, Novo Nordisk A/S, Måløv, Denmark., Hyman AA; Max Planck Institute of Cell Biology and Genetics (MPI-CBG), Dresden, Germany., Alberti S; Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany., Lorenzen N; Therapeutics Discovery, Novo Nordisk A/S, Måløv, Denmark., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.
Source: Nature chemistry [Nat Chem] 2026 Feb; Vol. 18 (2), pp. 246-257. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ausserwöger+H%22">Ausserwöger H</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Scrutton+R%22">Scrutton R</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fischer+CM%22">Fischer CM</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sneideris+T%22">Sneideris T</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Qian+D%22">Qian D</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22de+Csilléry+E%22">de Csilléry E</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Baronaite+I%22">Baronaite I</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Saar+KL%22">Saar KL</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Białek+AZ%22">Białek AZ</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Oeller+M%22">Oeller M</searchLink>; Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Krainer+G%22">Krainer G</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Biophysics, Institute of Molecular Biosciences (IMB), NAWI Graz, University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria.; Field of Excellence BioHealth, University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Franzmann+TM%22">Franzmann TM</searchLink>; Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wittmann+S%22">Wittmann S</searchLink>; Institute of Molecular Biology (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Iglesias-Artola+JM%22">Iglesias-Artola JM</searchLink>; Max Planck Institute of Cell Biology and Genetics (MPI-CBG), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Invernizzi+G%22">Invernizzi G</searchLink>; Therapeutics Discovery, Novo Nordisk A/S, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Hyman+AA%22">Hyman AA</searchLink>; Max Planck Institute of Cell Biology and Genetics (MPI-CBG), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Alberti+S%22">Alberti S</searchLink>; Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenzen+N%22">Lorenzen N</searchLink>; Therapeutics Discovery, Novo Nordisk A/S, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Knowles+TPJ%22">Knowles TPJ</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101499734%22">Nature chemistry</searchLink> [Nat Chem] 2026 Feb; Vol. 18 (2), pp. 246-257. <i>Date of Electronic Publication: </i>2026 Jan 29.
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