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Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.

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Title: Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.
Authors: Tocheny CE; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Buchwald JE; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Dahlke CD; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Fakih HH; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Morgan JS; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Summers A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Silva CA; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Jackson SO; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Lee JS; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Card MA; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Peterson C; Department of Comparative Pathobiology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Mercurio AM; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Shaw LM; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: leslie.shaw@umassmed.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2963-2982. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.
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  Data: <searchLink fieldCode="AU" term="%22Tocheny+CE%22">Tocheny CE</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Buchwald+JE%22">Buchwald JE</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Dahlke+CD%22">Dahlke CD</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Fakih+HH%22">Fakih HH</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+JS%22">Morgan JS</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Summers+A%22">Summers A</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Silva+CA%22">Silva CA</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+SO%22">Jackson SO</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JS%22">Lee JS</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Card+MA%22">Card MA</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Echeverria+D%22">Echeverria D</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+C%22">Peterson C</searchLink>; Department of Comparative Pathobiology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.<br /><searchLink fieldCode="AU" term="%22Mercurio+AM%22">Mercurio AM</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Khvorova+A%22">Khvorova A</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+LM%22">Shaw LM</searchLink>; Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: leslie.shaw@umassmed.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2963-2982. <i>Date of Electronic Publication: </i>2026 Jan 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 May 06
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