Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhea is dependent upon the IgG2:IgG3 antibody ratio.

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Title: Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhea is dependent upon the IgG2:IgG3 antibody ratio.
Authors: McKeand SA; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom., Faustini SE; Institute of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom., Cook A; The Binding Site, Birmingham, United Kingdom., Kennett N; The Binding Site, Birmingham, United Kingdom., Drayson MT; Institute of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom., Cunningham AF; Institute of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom., Henderson IR; Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia., Tang CM; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom., Ross JDC; Sexual Health and HIV, University Hospitals Birmingham, Birmingham, United Kingdom., Cole JA; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Rossiter-Pearson AE; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.
Source: MBio [mBio] 2026 Mar 11; Vol. 17 (3), pp. e0336723. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2150-7511
DOI:10.1128/mbio.03367-23