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The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.

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Title: The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.
Authors: Martins C; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal. claudia.martins@i3s.up.pt.; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal. claudia.martins@i3s.up.pt., Mitchell MJ; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Peer D; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.; Department of Materials Sciences and Engineering, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.; Cancer Biology Research Center, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel., Perrie Y; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Siegwart DJ; Department of Biomedical Engineering, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Alonso MJ; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain. mariaj.alonso@usc.es.; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain. mariaj.alonso@usc.es.; Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain. mariaj.alonso@usc.es.; Madrid Institute for Advanced Studies in Nanoscience (IMDEA), 28049, Madrid, Spain. mariaj.alonso@usc.es., Aparicio-Blanco J; Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal, 28040, Madrid, Spain. juan.aparicio.blanco@ucm.es.; Institute of Industrial Pharmacy, Complutense University of Madrid, Madrid, Spain. juan.aparicio.blanco@ucm.es.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 Jun; Vol. 16 (6), pp. 1667-1684. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Editorial
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
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  Data: The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.
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  Data: <searchLink fieldCode="AU" term="%22Martins+C%22">Martins C</searchLink>; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal. claudia.martins@i3s.up.pt.; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal. claudia.martins@i3s.up.pt.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Peer+D%22">Peer D</searchLink>; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.; Department of Materials Sciences and Engineering, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.; Cancer Biology Research Center, Tel Aviv University, 69978, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Perrie+Y%22">Perrie Y</searchLink>; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Siegwart+DJ%22">Siegwart DJ</searchLink>; Department of Biomedical Engineering, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Alonso+MJ%22">Alonso MJ</searchLink>; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain. mariaj.alonso@usc.es.; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain. mariaj.alonso@usc.es.; Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain. mariaj.alonso@usc.es.; Madrid Institute for Advanced Studies in Nanoscience (IMDEA), 28049, Madrid, Spain. mariaj.alonso@usc.es.<br /><searchLink fieldCode="AU" term="%22Aparicio-Blanco+J%22">Aparicio-Blanco J</searchLink>; Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal, 28040, Madrid, Spain. juan.aparicio.blanco@ucm.es.; Institute of Industrial Pharmacy, Complutense University of Madrid, Madrid, Spain. juan.aparicio.blanco@ucm.es.
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      – TitleFull: The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.
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              Text: 2026 Jun
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