Molecular features of human pathological tau distinguish tauopathy-associated dementias.
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| Title: | Molecular features of human pathological tau distinguish tauopathy-associated dementias. |
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| Authors: | Kumar M; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Schlaffner CN; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Data Analytics and Computational Statistics, Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany., Tang S; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Department of Biostatistics, Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Beuvink MA; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Viode A; Departments of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Mair W; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Jha M; Departments of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Uncu C; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Wesseling H; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Wang T; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Oakley DH; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Beerepoot P; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Xue J; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Connors TR; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Davis DA; UMMG Department of Neurology, Miller School of Medicine, Medical Campus, University of Miami, Miami, FL, USA., Frosch MP; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Spina SE; Memory and Aging Center, Department of Neurology and Pathology, University of California, San Francisco, San Francisco, CA, USA., Grinberg LT; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Seeley WW; Memory and Aging Center, Department of Neurology and Pathology, University of California, San Francisco, San Francisco, CA, USA., Miller BL; Memory and Aging Center, Department of Neurology and Pathology, University of California, San Francisco, San Francisco, CA, USA., Boxer AL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Kosik KS; Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Renard BY; Data Analytics and Computational Statistics, Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany., DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., McKee AC; Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA., Hyman BT; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Steen H; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Departments of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Steen JA; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: judith.steen@childrens.harvard.edu. |
| Source: | Cell [Cell] 2026 Feb 05; Vol. 189 (3), pp. 956-968.e13. Date of Electronic Publication: 2026 Jan 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41616780 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Molecular features of human pathological tau distinguish tauopathy-associated dementias. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kumar+M%22">Kumar M</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schlaffner+CN%22">Schlaffner CN</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Data Analytics and Computational Statistics, Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Tang+S%22">Tang S</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Department of Biostatistics, Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Beuvink+MA%22">Beuvink MA</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Viode+A%22">Viode A</searchLink>; Departments of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mair+W%22">Mair W</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jha+M%22">Jha M</searchLink>; Departments of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Uncu+C%22">Uncu C</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wesseling+H%22">Wesseling H</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oakley+DH%22">Oakley DH</searchLink>; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Beerepoot+P%22">Beerepoot P</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xue+J%22">Xue J</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Connors+TR%22">Connors TR</searchLink>; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Davis+DA%22">Davis DA</searchLink>; UMMG Department of Neurology, Miller School of Medicine, Medical Campus, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Frosch+MP%22">Frosch MP</searchLink>; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Murray+ME%22">Murray ME</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Spina+SE%22">Spina SE</searchLink>; Memory and Aging Center, Department of Neurology and Pathology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Grinberg+LT%22">Grinberg LT</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Seeley+WW%22">Seeley WW</searchLink>; Memory and Aging Center, Department of Neurology and Pathology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+BL%22">Miller BL</searchLink>; Memory and Aging Center, Department of Neurology and Pathology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Boxer+AL%22">Boxer AL</searchLink>; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Geschwind+DH%22">Geschwind DH</searchLink>; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kosik+KS%22">Kosik KS</searchLink>; Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dickson+DW%22">Dickson DW</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Renard+BY%22">Renard BY</searchLink>; Data Analytics and Computational Statistics, Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22DeTure+M%22">DeTure M</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22McKee+AC%22">McKee AC</searchLink>; Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hyman+BT%22">Hyman BT</searchLink>; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Steen+H%22">Steen H</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Departments of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Steen+JA%22">Steen JA</searchLink>; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: judith.steen@childrens.harvard.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Feb 05; Vol. 189 (3), pp. 956-968.e13. <i>Date of Electronic Publication: </i>2026 Jan 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413066 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4172 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200928674%22">00928674 </searchLink><i>NLM ISO Abbreviation: </i>Cell <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.cell.2025.12.036 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 956 Titles: – TitleFull: Molecular features of human pathological tau distinguish tauopathy-associated dementias. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kumar M – PersonEntity: Name: NameFull: Schlaffner CN – PersonEntity: Name: NameFull: Tang S – PersonEntity: Name: NameFull: Beuvink MA – PersonEntity: Name: NameFull: Viode A – PersonEntity: Name: NameFull: Mair W – PersonEntity: Name: NameFull: Jha M – PersonEntity: Name: NameFull: Uncu C – PersonEntity: Name: NameFull: Wesseling H – PersonEntity: Name: NameFull: Wang T – PersonEntity: Name: NameFull: Oakley DH – PersonEntity: Name: NameFull: Beerepoot P – PersonEntity: Name: NameFull: Xue J – PersonEntity: Name: NameFull: Connors TR – PersonEntity: Name: NameFull: Davis DA – PersonEntity: Name: NameFull: Frosch MP – PersonEntity: Name: NameFull: Murray ME – PersonEntity: Name: NameFull: Spina SE – PersonEntity: Name: NameFull: Grinberg LT – PersonEntity: Name: NameFull: Seeley WW – PersonEntity: Name: NameFull: Miller BL – PersonEntity: Name: NameFull: Boxer AL – PersonEntity: Name: NameFull: Geschwind DH – PersonEntity: Name: NameFull: Kosik KS – PersonEntity: Name: NameFull: Dickson DW – PersonEntity: Name: NameFull: Renard BY – PersonEntity: Name: NameFull: DeTure M – PersonEntity: Name: NameFull: McKee AC – PersonEntity: Name: NameFull: Hyman BT – PersonEntity: Name: NameFull: Steen H – PersonEntity: Name: NameFull: Steen JA IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 02 Text: 2026 Feb 05 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1097-4172 Numbering: – Type: volume Value: 189 – Type: issue Value: 3 Titles: – TitleFull: Cell Type: main |
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