GDF-11, GDF-15, Jag-1, and leptin in neuronal-derived extracellular vesicles as aging-related biomarkers to identify individuals at risk of Alzheimer's dementia: A pilot study.
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| Title: | GDF-11, GDF-15, Jag-1, and leptin in neuronal-derived extracellular vesicles as aging-related biomarkers to identify individuals at risk of Alzheimer's dementia: A pilot study. |
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| Authors: | Lanzillotta S; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Boccardi V; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy., Zulli B; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Napoli A; Computational Biology and Bioinformatics UOS, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168 Roma, Italy., Paolozzi G; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Angelini R; Institute for Complex Systems National Research Council (ISC-CNR), Sede Sapienza, and Department of Physics, Sapienza University, Piazzale Aldo Moro, 00185 Rome, Italy., Ruzicka B; Institute for Complex Systems National Research Council (ISC-CNR), Sede Sapienza, and Department of Physics, Sapienza University, Piazzale Aldo Moro, 00185 Rome, Italy., Fratini F; Department of Neuroscience, Italian National Health Institute (ISS), Viale Regina Elena, 299, 00161 Rome, Italy., Guazzarini AG; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden., Scamosci M; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy., Bastiani P; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy., Alunno M; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy., Westman E; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden; The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK., Di Domenico F; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Perluigi M; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Tramutola A; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Cecchetti R; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy., Mazza T; Computational Biology and Bioinformatics UOS, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168 Roma, Italy., Butterfield DA; Sanders-Brown Center On Aging, Department of Chemistry, University of Kentucky, 249 Chemistry-Physics Building, Lexington, KY 40506-0055, USA., Mecocci P; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. Electronic address: patrizia.mecocci@unipg.it., Barone E; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. Electronic address: eugenio.barone@uniroma1.it. |
| Source: | Neurobiology of disease [Neurobiol Dis] 2026 Mar; Vol. 220, pp. 107291. Date of Electronic Publication: 2026 Jan 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41616925 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: GDF-11, GDF-15, Jag-1, and leptin in neuronal-derived extracellular vesicles as aging-related biomarkers to identify individuals at risk of Alzheimer's dementia: A pilot study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lanzillotta+S%22">Lanzillotta S</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Boccardi+V%22">Boccardi V</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Zulli+B%22">Zulli B</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Napoli+A%22">Napoli A</searchLink>; Computational Biology and Bioinformatics UOS, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168 Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Paolozzi+G%22">Paolozzi G</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Angelini+R%22">Angelini R</searchLink>; Institute for Complex Systems National Research Council (ISC-CNR), Sede Sapienza, and Department of Physics, Sapienza University, Piazzale Aldo Moro, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ruzicka+B%22">Ruzicka B</searchLink>; Institute for Complex Systems National Research Council (ISC-CNR), Sede Sapienza, and Department of Physics, Sapienza University, Piazzale Aldo Moro, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fratini+F%22">Fratini F</searchLink>; Department of Neuroscience, Italian National Health Institute (ISS), Viale Regina Elena, 299, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Guazzarini+AG%22">Guazzarini AG</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Scamosci+M%22">Scamosci M</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Bastiani+P%22">Bastiani P</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Alunno+M%22">Alunno M</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Westman+E%22">Westman E</searchLink>; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden; The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Di+Domenico+F%22">Di Domenico F</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Perluigi+M%22">Perluigi M</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Tramutola+A%22">Tramutola A</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cecchetti+R%22">Cecchetti R</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Mazza+T%22">Mazza T</searchLink>; Computational Biology and Bioinformatics UOS, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168 Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Butterfield+DA%22">Butterfield DA</searchLink>; Sanders-Brown Center On Aging, Department of Chemistry, University of Kentucky, 249 Chemistry-Physics Building, Lexington, KY 40506-0055, USA.<br /><searchLink fieldCode="AU" term="%22Mecocci+P%22">Mecocci P</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132 Perugia, Italy; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. Electronic address: patrizia.mecocci@unipg.it.<br /><searchLink fieldCode="AU" term="%22Barone+E%22">Barone E</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. Electronic address: eugenio.barone@uniroma1.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2026 Mar; Vol. 220, pp. 107291. <i>Date of Electronic Publication: </i>2026 Jan 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9500169 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-953X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209699961%22">09699961 </searchLink><i>NLM ISO Abbreviation: </i>Neurobiol Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41616925 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nbd.2026.107291 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107291 Titles: – TitleFull: GDF-11, GDF-15, Jag-1, and leptin in neuronal-derived extracellular vesicles as aging-related biomarkers to identify individuals at risk of Alzheimer's dementia: A pilot study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lanzillotta S – PersonEntity: Name: NameFull: Boccardi V – PersonEntity: Name: NameFull: Zulli B – PersonEntity: Name: NameFull: Napoli A – PersonEntity: Name: NameFull: Paolozzi G – PersonEntity: Name: NameFull: Angelini R – PersonEntity: Name: NameFull: Ruzicka B – PersonEntity: Name: NameFull: Fratini F – PersonEntity: Name: NameFull: Guazzarini AG – PersonEntity: Name: NameFull: Scamosci M – PersonEntity: Name: NameFull: Bastiani P – PersonEntity: Name: NameFull: Alunno M – PersonEntity: Name: NameFull: Westman E – PersonEntity: Name: NameFull: Di Domenico F – PersonEntity: Name: NameFull: Perluigi M – PersonEntity: Name: NameFull: Tramutola A – PersonEntity: Name: NameFull: Cecchetti R – PersonEntity: Name: NameFull: Mazza T – PersonEntity: Name: NameFull: Butterfield DA – PersonEntity: Name: NameFull: Mecocci P – PersonEntity: Name: NameFull: Barone E IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1095-953X Numbering: – Type: volume Value: 220 Titles: – TitleFull: Neurobiology of disease Type: main |
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