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Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors.

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Title: Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors.
Authors: Kallupi M; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. mkallupi@health.ucsd.edu., de Guglielmo G; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Carrette LLG; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Simpson S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Kononoff J; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA., Kimbrough A; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Smith LC; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Shankar K; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA., Avelar A; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Conlisk D; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA., Brennan M; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Tieu L; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sedighim S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Boomhower B; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Maturin L; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Fannon MJ; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Martinez A; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Crook C; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Dirik S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Velarde N; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Schweitzer P; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Bonnet-Zahedi S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sneddon E; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Plasil S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Morgan AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Othman DN; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sichel B; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Peng B; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Chitre AS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Polesskaya O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Lau J; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Vang A; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Solberg Woods LC; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., George O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. olgeorge@health.ucsd.edu.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 May; Vol. 51 (6), pp. 1074-1083. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
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  Data: Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors.
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Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22George+O%22">George O</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. olgeorge@health.ucsd.edu.
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