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Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations.

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Title: Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations.
Authors: Gan S; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. shiminggan@zju.edu.cn., Li Y; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Yin L; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Yang X; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China., Lou C; Department of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Li S; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Lin M; School of Science, China Pharmaceutical University, Nanjing, 211198, China., Li X; School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Xu W; Department of Urology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430033, China., Zhou J; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China., Hu P; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China., Yao Z; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Yuan Y; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Sheng J; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Zhang C; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China. chenzhang_ired@fudan.edu.cn.; Asian Academy of Anti-aging Research and Translational Medicine (Shenzhen), Shenzhen, 518000, China. chenzhang_ired@fudan.edu.cn., Yang W; Department of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. Yangwei@zju.edu.cn.; GuiZhou University Medical College, Guiyang, 550025, China. Yangwei@zju.edu.cn., Li Y; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. liyoujiang26@zju.edu.cn., Huang H; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. huanghefg@zju.edu.cn.; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China. huanghefg@zju.edu.cn.; Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education) and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. huanghefg@zju.edu.cn.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China. huanghefg@zju.edu.cn.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Mar; Vol. 18 (3), pp. 916-942. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations.
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  Data: <searchLink fieldCode="AU" term="%22Gan+S%22">Gan S</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. shiminggan@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Yin+L%22">Yin L</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China.<br /><searchLink fieldCode="AU" term="%22Lou+C%22">Lou C</searchLink>; Department of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; School of Science, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; School of Basic Medical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Department of Urology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430033, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China.<br /><searchLink fieldCode="AU" term="%22Hu+P%22">Hu P</searchLink>; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China.<br /><searchLink fieldCode="AU" term="%22Yao+Z%22">Yao Z</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Sheng+J%22">Sheng J</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China. chenzhang_ired@fudan.edu.cn.; Asian Academy of Anti-aging Research and Translational Medicine (Shenzhen), Shenzhen, 518000, China. chenzhang_ired@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+W%22">Yang W</searchLink>; Department of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. Yangwei@zju.edu.cn.; GuiZhou University Medical College, Guiyang, 550025, China. Yangwei@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. liyoujiang26@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Reproductive Medicine, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. huanghefg@zju.edu.cn.; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200001, China. huanghefg@zju.edu.cn.; Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education) and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. huanghefg@zju.edu.cn.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China. huanghefg@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 Mar; Vol. 18 (3), pp. 916-942. <i>Date of Electronic Publication: </i>2026 Jan 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
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