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A Multivalent Dengue Fusion Protein ΔcNS1-cEDIII-ΔnNS3 Confers Cross-Serotype Protection and Durable Immunity in Mice.

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Title: A Multivalent Dengue Fusion Protein ΔcNS1-cEDIII-ΔnNS3 Confers Cross-Serotype Protection and Durable Immunity in Mice.
Authors: Pi MF; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Liao WC; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Li XY; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Cheng MH; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Tsai CE; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Lai YC; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Leadgene Biomedical, Inc., Tainan, Taiwan., Lin HH; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; SIDSCO Biomedical Co. Ltd., Kaohsiung, Taiwan., Chuang YC; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Leadgene Biomedical, Inc., Tainan, Taiwan., Tseng CK; SIDSCO Biomedical Co. Ltd., Kaohsiung, Taiwan., Lin YS; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Chang CP; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan., Ho TS; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Pediatrics, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.; Department of Pediatrics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan., Syu GD; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan., Yeh TM; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan., Wang JR; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan., Chu JJH; Department of Microbiology and Immunology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yu CY; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan., Wan SW; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Source: Journal of medical virology [J Med Virol] 2026 Feb; Vol. 98 (2), pp. e70822.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
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  Data: A Multivalent Dengue Fusion Protein ΔcNS1-cEDIII-ΔnNS3 Confers Cross-Serotype Protection and Durable Immunity in Mice.
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  Data: <searchLink fieldCode="AU" term="%22Pi+MF%22">Pi MF</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+WC%22">Liao WC</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+XY%22">Li XY</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+MH%22">Cheng MH</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CE%22">Tsai CE</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+YC%22">Lai YC</searchLink>; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Leadgene Biomedical, Inc., Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HH%22">Lin HH</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; SIDSCO Biomedical Co. Ltd., Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+YC%22">Chuang YC</searchLink>; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Leadgene Biomedical, Inc., Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+CK%22">Tseng CK</searchLink>; SIDSCO Biomedical Co. Ltd., Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YS%22">Lin YS</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CP%22">Chang CP</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+TS%22">Ho TS</searchLink>; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Pediatrics, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.; Department of Pediatrics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Syu+GD%22">Syu GD</searchLink>; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+TM%22">Yeh TM</searchLink>; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JR%22">Wang JR</searchLink>; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+JJH%22">Chu JJH</searchLink>; Department of Microbiology and Immunology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+CY%22">Yu CY</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wan+SW%22">Wan SW</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
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              Text: 2026 Feb
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