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A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol.

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Title: A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol.
Authors: Förster F; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany; IMB gGmbH, Mainz, Rhineland-Palatinate, 55128, Germany. Electronic address: franz.foerster@imise.uni-leipzig.de., Horn K; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany., Pott J; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, United Kingdom., Delgado GE; LURIC Study GmbH, Aystetten, D-86482, Germany., Kleber ME; LURIC Study GmbH, Aystetten, D-86482, Germany; Department of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany; SYNLAB MVZ Humangenetik Mannheim, Mannheim, 68163, Germany., März W; Department of Medicine III (Cardiology, Pneumonology, Angiology), Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, 69117, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Augsburg, 86156, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, 8010, Austria., Moissl-Blanke AP; Department of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, 8010, Austria; Department of Angiology, Kantonsspital St. Gallen, HOCH Health Ostschweiz, St. Gallen, 9000, Switzerland., Waldenberger M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Grallert H; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Faculty of Medicine, Ludwig Maximilians University, Munich, 81377, Germany., Gieger C; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany., Baber R; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Saxony, 04103, Germany., Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany., Isermann B; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Saxony, 04103, Germany., Thiery J; Medical Faculty, Christian-Albrechts-Universität zu Kiel, Kiel, 24118, Germany., Kovacs P; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, 04103, Germany., Tönjes A; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, 04103, Germany., Stumvoll M; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, 04103, Germany., Gylling H; Heart and Lung Center, Cardiology, University of Helsinki and Helsinki Univ. Hospital, Helsinki, 00290, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33521, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, 33521, Finland., Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, 33521, Finland., Raitakari O; Centre for Population Health Research, University of Turku and Turku University Hospital; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20520, Finland., Ceglarek U; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Saxony, 04103, Germany., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany. Electronic address: Markus.Scholz@imise.uni-leipzig.de.
Source: EBioMedicine [EBioMedicine] 2026 Feb; Vol. 124, pp. 106144. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol.
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  Data: <searchLink fieldCode="AU" term="%22Förster+F%22">Förster F</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany; IMB gGmbH, Mainz, Rhineland-Palatinate, 55128, Germany. Electronic address: franz.foerster@imise.uni-leipzig.de.<br /><searchLink fieldCode="AU" term="%22Horn+K%22">Horn K</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany.<br /><searchLink fieldCode="AU" term="%22Pott+J%22">Pott J</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Delgado+GE%22">Delgado GE</searchLink>; LURIC Study GmbH, Aystetten, D-86482, Germany.<br /><searchLink fieldCode="AU" term="%22Kleber+ME%22">Kleber ME</searchLink>; LURIC Study GmbH, Aystetten, D-86482, Germany; Department of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany; SYNLAB MVZ Humangenetik Mannheim, Mannheim, 68163, Germany.<br /><searchLink fieldCode="AU" term="%22März+W%22">März W</searchLink>; Department of Medicine III (Cardiology, Pneumonology, Angiology), Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, 69117, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Augsburg, 86156, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, 8010, Austria.<br /><searchLink fieldCode="AU" term="%22Moissl-Blanke+AP%22">Moissl-Blanke AP</searchLink>; Department of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.<br /><searchLink fieldCode="AU" term="%22Silbernagel+G%22">Silbernagel G</searchLink>; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, 8010, Austria; Department of Angiology, Kantonsspital St. Gallen, HOCH Health Ostschweiz, St. Gallen, 9000, Switzerland.<br /><searchLink fieldCode="AU" term="%22Waldenberger+M%22">Waldenberger M</searchLink>; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Grallert+H%22">Grallert H</searchLink>; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+A%22">Peters A</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Faculty of Medicine, Ludwig Maximilians University, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Gieger+C%22">Gieger C</searchLink>; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany.<br /><searchLink fieldCode="AU" term="%22Baber+R%22">Baber R</searchLink>; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Saxony, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Kirsten+H%22">Kirsten H</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany.<br /><searchLink fieldCode="AU" term="%22Loeffler+M%22">Loeffler M</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Isermann+B%22">Isermann B</searchLink>; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Saxony, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Thiery+J%22">Thiery J</searchLink>; Medical Faculty, Christian-Albrechts-Universität zu Kiel, Kiel, 24118, Germany.<br /><searchLink fieldCode="AU" term="%22Kovacs+P%22">Kovacs P</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, D-85764, Germany; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Tönjes+A%22">Tönjes A</searchLink>; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Stumvoll+M%22">Stumvoll M</searchLink>; 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Hospital, Helsinki, 00290, Finland.<br /><searchLink fieldCode="AU" term="%22Kähönen+M%22">Kähönen M</searchLink>; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33521, Finland.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+T%22">Lehtimäki T</searchLink>; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, 33521, Finland.<br /><searchLink fieldCode="AU" term="%22Mishra+PP%22">Mishra PP</searchLink>; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, 33521, Finland.<br /><searchLink fieldCode="AU" term="%22Raitakari+O%22">Raitakari O</searchLink>; Centre for Population Health Research, University of Turku and Turku University Hospital; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20520, Finland.<br /><searchLink fieldCode="AU" term="%22Ceglarek+U%22">Ceglarek U</searchLink>; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Saxony, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Scholz+M%22">Scholz M</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Saxony, 04107, Germany; LIFE - Leipziger Forschungszentrum für Zivilisationserkrankungen, Leipzig, Saxony, 04103, Germany. Electronic address: Markus.Scholz@imise.uni-leipzig.de.
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