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Immediate or high-dose antituberculosis therapy for HIV-related sepsis in Tanzania and Uganda (ATLAS): a phase 3, open-label, randomised, controlled, 2 × 2 factorial, superiority trial.

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Title: Immediate or high-dose antituberculosis therapy for HIV-related sepsis in Tanzania and Uganda (ATLAS): a phase 3, open-label, randomised, controlled, 2 × 2 factorial, superiority trial.
Authors: Heysell SK; University of Virginia, Charlottesville, VA, USA. Electronic address: skh8r@uvahealth.org., Mpagama SG; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania., Nuwagira E; Mbarara University Science and Technology, Mbarara, Uganda., Said B; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania., Conaway M; University of Virginia, Charlottesville, VA, USA., Null M; University of Virginia, Charlottesville, VA, USA., Thomas TA; University of Virginia, Charlottesville, VA, USA., Boulware DR; University of Minnesota, Minneapolis, MN, USA., Otoupalova E; Tulane University, New Orleans, LA, USA., Arinaitwe R; Mbarara University Science and Technology, Mbarara, Uganda., Mushagara R; Mbarara University Science and Technology, Mbarara, Uganda., Edwards L; Stanford University, Palo Alto, CA, USA., Buzaare P; Mbarara University Science and Technology, Mbarara, Uganda., Ngoma AM; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania., Muganzi D; Mbarara University Science and Technology, Mbarara, Uganda., Gidoi G; Mbarara University Science and Technology, Mbarara, Uganda., Jjunju S; Mbarara University Science and Technology, Mbarara, Uganda., Gulinja A; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania., Rimoy AG; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania., Mwita FC; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania., Kidola J; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania., Atwiine O; Fort Portal Regional Referral Hospital, Fort Portal, Uganda., Ocaaki D; Fort Portal Regional Referral Hospital, Fort Portal, Uganda., Munyambalu DK; Fort Portal Regional Referral Hospital, Fort Portal, Uganda., Liu J; University of Virginia, Charlottesville, VA, USA., Ampaire L; Mbarara University Science and Technology, Mbarara, Uganda., Mujaga B; Kilimanjaro Clinical Research Institute, Moshi, Tanzania., Rao P; University of Virginia, Charlottesville, VA, USA., Liyoyo A; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania., Sariko M; Kilimanjaro Clinical Research Institute, Moshi, Tanzania., Muzoora C; Mbarara University Science and Technology, Mbarara, Uganda., Moore CC; University of Virginia, Charlottesville, VA, USA.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2026 Jun; Vol. 26 (6), pp. 601-613. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Equivalence Trial; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immediate or high-dose antituberculosis therapy for HIV-related sepsis in Tanzania and Uganda (ATLAS): a phase 3, open-label, randomised, controlled, 2 × 2 factorial, superiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Heysell+SK%22">Heysell SK</searchLink>; University of Virginia, Charlottesville, VA, USA. Electronic address: skh8r@uvahealth.org.<br /><searchLink fieldCode="AU" term="%22Mpagama+SG%22">Mpagama SG</searchLink>; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Nuwagira+E%22">Nuwagira E</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Said+B%22">Said B</searchLink>; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Conaway+M%22">Conaway M</searchLink>; University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Null+M%22">Null M</searchLink>; University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+TA%22">Thomas TA</searchLink>; University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Boulware+DR%22">Boulware DR</searchLink>; University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Otoupalova+E%22">Otoupalova E</searchLink>; Tulane University, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Arinaitwe+R%22">Arinaitwe R</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Mushagara+R%22">Mushagara R</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Edwards+L%22">Edwards L</searchLink>; Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Buzaare+P%22">Buzaare P</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Ngoma+AM%22">Ngoma AM</searchLink>; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Muganzi+D%22">Muganzi D</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Gidoi+G%22">Gidoi G</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Jjunju+S%22">Jjunju S</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Gulinja+A%22">Gulinja A</searchLink>; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Rimoy+AG%22">Rimoy AG</searchLink>; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Mwita+FC%22">Mwita FC</searchLink>; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.<br /><searchLink fieldCode="AU" term="%22Kidola+J%22">Kidola J</searchLink>; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.<br /><searchLink fieldCode="AU" term="%22Atwiine+O%22">Atwiine O</searchLink>; Fort Portal Regional Referral Hospital, Fort Portal, Uganda.<br /><searchLink fieldCode="AU" term="%22Ocaaki+D%22">Ocaaki D</searchLink>; Fort Portal Regional Referral Hospital, Fort Portal, Uganda.<br /><searchLink fieldCode="AU" term="%22Munyambalu+DK%22">Munyambalu DK</searchLink>; Fort Portal Regional Referral Hospital, Fort Portal, Uganda.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Ampaire+L%22">Ampaire L</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Mujaga+B%22">Mujaga B</searchLink>; Kilimanjaro Clinical Research Institute, Moshi, Tanzania.<br /><searchLink fieldCode="AU" term="%22Rao+P%22">Rao P</searchLink>; University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Liyoyo+A%22">Liyoyo A</searchLink>; Kibong'oto Infectious Diseases Hospital, Siha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Sariko+M%22">Sariko M</searchLink>; Kilimanjaro Clinical Research Institute, Moshi, Tanzania.<br /><searchLink fieldCode="AU" term="%22Muzoora+C%22">Muzoora C</searchLink>; Mbarara University Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Moore+CC%22">Moore CC</searchLink>; University of Virginia, Charlottesville, VA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2026 Jun; Vol. 26 (6), pp. 601-613. <i>Date of Electronic Publication: </i>2026 Jan 28.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Equivalence Trial; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130150 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-4457 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214733099%22">14733099 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Infect Dis <i>Subsets: </i>MEDLINE
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