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Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C.

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Title: Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C.
Authors: Condakes ML; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA. matthew@condakes.com., Zhang Z; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Danahy DB; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Moore RR; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Lakkaraju SK; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Zhuo X; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Amako Y; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Borzilleri RM; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Balachander SB; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Chourb L; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Civiello RL; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Dongre AR; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Downes DP; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Drexler DM; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Dudiak BM; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Dzhekieva L; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., El-Samin M; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Fink BE; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Frederick K; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Huang C; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Khan J; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Lees E; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Levins CG; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., McCarthy C; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Mintier GA; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Mosure K; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Parker MF; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Powles R; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Qi J; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Ruzanov M; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Sharma S; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Sheriff S; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Singh AK; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Stedman J; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Szapiel N; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Thompson RL; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Vaccaro W; Bristol Myers Squibb, Route 206 & Province Line Rd., Princeton, NJ, USA., Wang T; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Yang T; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., You D; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Meyer MJ; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Bronson JJ; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA., Stewart ML; Bristol Myers Squibb, 250 Water St., Cambridge, MA, USA. 4michellestewart@gmail.com.
Source: Nature communications [Nat Commun] 2026 Jan 31; Vol. 17 (1). Date of Electronic Publication: 2026 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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