Agonistic GITR treatment enhances antitumor immune responses and suppresses tumor progression in pancreatic ductal adenocarcinoma.

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Title: Agonistic GITR treatment enhances antitumor immune responses and suppresses tumor progression in pancreatic ductal adenocarcinoma.
Authors: Robatel S; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland.; Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Hillen H; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland., Mutisheva I; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland., Müller JC; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Louvain, Belgium., Wartenberg M; Division of Surgical Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland., Ma F; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Bäriswyl L; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland., Evenepoel J; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Louvain, Belgium.; Laboratory for Enteric Neuroscience (LENS), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Louvain, Belgium., Scheele CLGJ; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Louvain, Belgium., Lee DJ; The Lundquist Institute for Biomedical Innovation, Torrance, CA, USA.; Division of Dermatology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Modlin RL; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Division of Dermatology, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Kessler U; Department of Pediatric Surgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland., Nobis M; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK., Z'graggen K; Swiss Pancreas Clinic, Bern, Switzerland., Schenk M; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland. mirjam.schenk@unibe.ch.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland. mirjam.schenk@unibe.ch.
Source: Journal of gastroenterology [J Gastroenterol] 2026 May; Vol. 61 (5), pp. 638-659. Date of Electronic Publication: 2026 Feb 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Agonistic GITR treatment enhances antitumor immune responses and suppresses tumor progression in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Robatel+S%22">Robatel S</searchLink>; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland.; Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hillen+H%22">Hillen H</searchLink>; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mutisheva+I%22">Mutisheva I</searchLink>; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Müller+JC%22">Müller JC</searchLink>; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Louvain, Belgium.<br /><searchLink fieldCode="AU" term="%22Wartenberg+M%22">Wartenberg M</searchLink>; Division of Surgical Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ma+F%22">Ma F</searchLink>; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Bäriswyl+L%22">Bäriswyl L</searchLink>; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Evenepoel+J%22">Evenepoel J</searchLink>; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Louvain, Belgium.; Laboratory for Enteric Neuroscience (LENS), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Louvain, Belgium.<br /><searchLink fieldCode="AU" term="%22Scheele+CLGJ%22">Scheele CLGJ</searchLink>; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Louvain, Belgium.<br /><searchLink fieldCode="AU" term="%22Lee+DJ%22">Lee DJ</searchLink>; The Lundquist Institute for Biomedical Innovation, Torrance, CA, USA.; Division of Dermatology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Modlin+RL%22">Modlin RL</searchLink>; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Division of Dermatology, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kessler+U%22">Kessler U</searchLink>; Department of Pediatric Surgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nobis+M%22">Nobis M</searchLink>; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Z'graggen+K%22">Z'graggen K</searchLink>; Swiss Pancreas Clinic, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schenk+M%22">Schenk M</searchLink>; Division of Experimental Pathology, Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Bern, Switzerland. mirjam.schenk@unibe.ch.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland. mirjam.schenk@unibe.ch.
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  Data: <searchLink fieldCode="JN" term="%229430794%22">Journal of gastroenterology</searchLink> [J Gastroenterol] 2026 May; Vol. 61 (5), pp. 638-659. <i>Date of Electronic Publication: </i>2026 Feb 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>9430794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-5922 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209441174%22">09441174 </searchLink><i>NLM ISO Abbreviation: </i>J Gastroenterol <i>Subsets: </i>MEDLINE
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