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Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite.

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Title: Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite.
Authors: Yang YH; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., Yao CY; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lin MJ; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Huang KT; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., Lin YH; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan., Huang YH; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan., Chiu IH; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan., Lai SK; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei, Taiwan., Chen CY; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., Yang YC; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan., Hsu CL; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Hsu JS; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., Chen CY; Department of Biomechatronics Engineering, National Taiwan University, Taipei, Taiwan., Chen PL; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: paylong@ntu.edu.tw.
Source: Journal of advanced research [J Adv Res] 2026 Jan 30. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite.
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  Data: <searchLink fieldCode="AU" term="%22Yang+YH%22">Yang YH</searchLink>; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yao+CY%22">Yao CY</searchLink>; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+MJ%22">Lin MJ</searchLink>; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Huang+KT%22">Huang KT</searchLink>; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YH%22">Huang YH</searchLink>; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+IH%22">Chiu IH</searchLink>; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+SK%22">Lai SK</searchLink>; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+YC%22">Yang YC</searchLink>; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CL%22">Hsu CL</searchLink>; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+JS%22">Hsu JS</searchLink>; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Department of Biomechatronics Engineering, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PL%22">Chen PL</searchLink>; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: paylong@ntu.edu.tw.
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        Value: 10.1016/j.jare.2026.01.053
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