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Rationale and design of a parallel randomised trial of a plant-based intensive lifestyle intervention for diabetes remission: The REmission of diabetes using a PlAnt-based weight loss InteRvention (REPAIR) trial.

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Title: Rationale and design of a parallel randomised trial of a plant-based intensive lifestyle intervention for diabetes remission: The REmission of diabetes using a PlAnt-based weight loss InteRvention (REPAIR) trial.
Authors: McKay B; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada., El Chaar D; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada., Paquette M; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada., Vallis M; Department of Family Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Sherifali D; School of Nursing, McMaster University, Hamilton, Ontario, Canada.; McMaster Evidence Review and Synthesis Team, McMaster University, Hamilton, Ontario, Canada., Oh P; Toronto Rehabilitation Institute, KITE Research Institute, Toronto, Ontario, Canada., Marzolini S; Toronto Rehabilitation Institute, KITE Research Institute, Toronto, Ontario, Canada., Dasgupta K; Department of Medicine, McGill University and Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Booth G; MAP Centre for Urban Health Solutions, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada., Lean M; Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Gerstein HC; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada., Salas-Salvadó J; Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Reus, Tarragona, Spain.; Instituto de Salud Carlos III, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain., Beaudry JL; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Marinangeli CPF; Centre for Regulatory Research and Innovation, Protein Industries Canada, Regina, Saskatchewan, Canada., de Souza RJ; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.; Mary Heersink School of Global Health and Social Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Leiter LA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada., Kendall CWC; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Jenkins DJA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada., Sievenpiper JL; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada., Chiavaroli L; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Source: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2026 Apr; Vol. 28 (4), pp. 2627-2641. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41623136
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Rationale and design of a parallel randomised trial of a plant-based intensive lifestyle intervention for diabetes remission: The REmission of diabetes using a PlAnt-based weight loss InteRvention (REPAIR) trial.
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  Data: <searchLink fieldCode="AU" term="%22McKay+B%22">McKay B</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22El+Chaar+D%22">El Chaar D</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Paquette+M%22">Paquette M</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Vallis+M%22">Vallis M</searchLink>; Department of Family Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Sherifali+D%22">Sherifali D</searchLink>; School of Nursing, McMaster University, Hamilton, Ontario, Canada.; McMaster Evidence Review and Synthesis Team, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Oh+P%22">Oh P</searchLink>; Toronto Rehabilitation Institute, KITE Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Marzolini+S%22">Marzolini S</searchLink>; Toronto Rehabilitation Institute, KITE Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dasgupta+K%22">Dasgupta K</searchLink>; Department of Medicine, McGill University and Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Booth+G%22">Booth G</searchLink>; MAP Centre for Urban Health Solutions, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lean+M%22">Lean M</searchLink>; Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gerstein+HC%22">Gerstein HC</searchLink>; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Salas-Salvadó+J%22">Salas-Salvadó J</searchLink>; Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Reus, Tarragona, Spain.; Instituto de Salud Carlos III, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.<br /><searchLink fieldCode="AU" term="%22Beaudry+JL%22">Beaudry JL</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Marinangeli+CPF%22">Marinangeli CPF</searchLink>; Centre for Regulatory Research and Innovation, Protein Industries Canada, Regina, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22de+Souza+RJ%22">de Souza RJ</searchLink>; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.; Mary Heersink School of Global Health and Social Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Leiter+LA%22">Leiter LA</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kendall+CWC%22">Kendall CWC</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Jenkins+DJA%22">Jenkins DJA</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sievenpiper+JL%22">Sievenpiper JL</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chiavaroli+L%22">Chiavaroli L</searchLink>; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%22100883645%22">Diabetes, obesity & metabolism</searchLink> [Diabetes Obes Metab] 2026 Apr; Vol. 28 (4), pp. 2627-2641. <i>Date of Electronic Publication: </i>2026 Feb 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100883645 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1463-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214628902%22">14628902 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes Obes Metab <i>Subsets: </i>MEDLINE
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        Text: English
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