Orphan drug uttroside B impedes MASH progression and HCC development in experimental models.

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Title: Orphan drug uttroside B impedes MASH progression and HCC development in experimental models.
Authors: Rayginia TP; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram 695011, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India., Keerthana CK; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram 695011, Kerala, India., Aiswarya SU; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India., Shifana SC; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India., Jannet S; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Varma SS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India., Maria Joy P; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Swetha M; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., James S; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Aparna JS; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Vijayan Y; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Retnakumary AP; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Nath LR; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi 682041, Kerala, India., Kalimuthu K; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Jaikumar VS; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Sundaram S; Department of Pathology, Government Medical College, Kottayam 686008, Kerala, India., Anto NP; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel., Isakov N; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel., Harikumar KB; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Lankalapalli RS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India., Anto RJ; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2025 Oct 10; Vol. 8 (2), pp. 101626. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process
Database: MEDLINE Ultimate
Description
ISSN:2589-5559
DOI:10.1016/j.jhepr.2025.101626