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Orphan drug uttroside B impedes MASH progression and HCC development in experimental models.

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Title: Orphan drug uttroside B impedes MASH progression and HCC development in experimental models.
Authors: Rayginia TP; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram 695011, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India., Keerthana CK; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram 695011, Kerala, India., Aiswarya SU; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India., Shifana SC; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India., Jannet S; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Varma SS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India., Maria Joy P; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Swetha M; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., James S; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Aparna JS; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Vijayan Y; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Retnakumary AP; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Nath LR; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi 682041, Kerala, India., Kalimuthu K; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Jaikumar VS; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Sundaram S; Department of Pathology, Government Medical College, Kottayam 686008, Kerala, India., Anto NP; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel., Isakov N; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel., Harikumar KB; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India., Lankalapalli RS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India., Anto RJ; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2025 Oct 10; Vol. 8 (2), pp. 101626. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process
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  Data: Orphan drug uttroside B impedes MASH progression and HCC development in experimental models.
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  Data: <searchLink fieldCode="AU" term="%22Rayginia+TP%22">Rayginia TP</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram 695011, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Keerthana+CK%22">Keerthana CK</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Biotechnology, University of Kerala, Thiruvananthapuram 695011, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Aiswarya+SU%22">Aiswarya SU</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Shifana+SC%22">Shifana SC</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Jannet+S%22">Jannet S</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Varma+SS%22">Varma SS</searchLink>; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Maria+Joy+P%22">Maria Joy P</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Swetha+M%22">Swetha M</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22James+S%22">James S</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Aparna+JS%22">Aparna JS</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Vijayan+Y%22">Vijayan Y</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Retnakumary+AP%22">Retnakumary AP</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Nath+LR%22">Nath LR</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi 682041, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Kalimuthu+K%22">Kalimuthu K</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Jaikumar+VS%22">Jaikumar VS</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Sundaram+S%22">Sundaram S</searchLink>; Department of Pathology, Government Medical College, Kottayam 686008, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Anto+NP%22">Anto NP</searchLink>; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel.<br /><searchLink fieldCode="AU" term="%22Isakov+N%22">Isakov N</searchLink>; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel.<br /><searchLink fieldCode="AU" term="%22Harikumar+KB%22">Harikumar KB</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Lankalapalli+RS%22">Lankalapalli RS</searchLink>; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.<br /><searchLink fieldCode="AU" term="%22Anto+RJ%22">Anto RJ</searchLink>; Division of Cancer Research, BRIC-Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thiruvananthapuram 695014, Kerala, India.; Centre of Excellence in Nutraceuticals, KSCSTE, Government of Kerala, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.; Molecular Bioassay Laboratory, Institute of Advanced Virology, Bio360 Life Science Park, Thiruvananthapuram, 695317, Kerala, India.
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  Data: <searchLink fieldCode="JN" term="%22101761237%22">JHEP reports : innovation in hepatology</searchLink> [JHEP Rep] 2025 Oct 10; Vol. 8 (2), pp. 101626. <i>Date of Electronic Publication: </i>2025 Oct 10 (<i>Print Publication: </i>2026).
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