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Pharmacokinetics, efficacy, and safety of a novel aripiprazole microsphere-based long-acting injectable formulation for schizophrenia: A multicenter, randomized controlled trial.

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Title: Pharmacokinetics, efficacy, and safety of a novel aripiprazole microsphere-based long-acting injectable formulation for schizophrenia: A multicenter, randomized controlled trial.
Authors: Li AN; National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital Affiliated to Capital Medical University, Beijing, 100088, China., Jin SC; Early Intervention Department, The Fourth People's Hospital of Hefei, Hefei, 230022, China., Shang DW; Drug Clinical Trial Institution, The Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, 510370, China., Guo JX; Medical Affairs Department, The Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, 510370, China., Lin HL; Women's Psychopsychology Department, Xi'an Mental Health Center, Xi'an, 710061, China., Zhang M; Psychiatric Department 6, Shandong Daizhuang Hospital, Jining, Shandong, 272000, China., Wei B; Jiangxi Provincial Psychiatric Hospital, Nanchang, 220029, China., Wan F; Female Acute Care Ward 3, Shenzhen Kangning Hospital, Shenzhen, Guangdong, 518118, China., Tan YL; Beijing Huilongguan Hospital, Beijing, 100096, China., Wang LL; Psychiatric Department 8, Tianjin Anding Hospital, Tianjin, 300222, China., Zhou JC; The 11th People's Hospital of Chongqing, Chongqing, 400030, China., Liu P; Psychosomatic Medicine Department, Deyang People's Hospital, Deyang, Sichuan, 618000, China., Fan LL; Drug Clinical Trial Institution, Deyang People's Hospital, Deyang, Sichuan, 618000, China., Sun JS; Premium Psychiatric Services Department, The Third People's Hospital of Huzhou, Huzhou, Zhejiang, 313000, China., Chen B; Zhuhai Livzon Microsphere Technology Co., Ltd., Livzon Pharmaceutical Group Inc., Zhuhai, Guangdong, 519090, China., Cui Y; Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, 100191, China., Wang G; National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital Affiliated to Capital Medical University, Beijing, 100088, China.
Source: Journal of pharmaceutical analysis [J Pharm Anal] 2026 Jan; Vol. 16 (1), pp. 101350. Date of Electronic Publication: 2025 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Xi'an Jiaotong University Country of Publication: China NLM ID: 101579451 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-0883 (Electronic) Linking ISSN: 22140883 NLM ISO Abbreviation: J Pharm Anal Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacokinetics, efficacy, and safety of a novel aripiprazole microsphere-based long-acting injectable formulation for schizophrenia: A multicenter, randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Li+AN%22">Li AN</searchLink>; National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital Affiliated to Capital Medical University, Beijing, 100088, China.<br /><searchLink fieldCode="AU" term="%22Jin+SC%22">Jin SC</searchLink>; Early Intervention Department, The Fourth People's Hospital of Hefei, Hefei, 230022, China.<br /><searchLink fieldCode="AU" term="%22Shang+DW%22">Shang DW</searchLink>; Drug Clinical Trial Institution, The Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, 510370, China.<br /><searchLink fieldCode="AU" term="%22Guo+JX%22">Guo JX</searchLink>; Medical Affairs Department, The Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, 510370, China.<br /><searchLink fieldCode="AU" term="%22Lin+HL%22">Lin HL</searchLink>; Women's Psychopsychology Department, Xi'an Mental Health Center, Xi'an, 710061, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Psychiatric Department 6, Shandong Daizhuang Hospital, Jining, Shandong, 272000, China.<br /><searchLink fieldCode="AU" term="%22Wei+B%22">Wei B</searchLink>; Jiangxi Provincial Psychiatric Hospital, Nanchang, 220029, China.<br /><searchLink fieldCode="AU" term="%22Wan+F%22">Wan F</searchLink>; Female Acute Care Ward 3, Shenzhen Kangning Hospital, Shenzhen, Guangdong, 518118, China.<br /><searchLink fieldCode="AU" term="%22Tan+YL%22">Tan YL</searchLink>; Beijing Huilongguan Hospital, Beijing, 100096, China.<br /><searchLink fieldCode="AU" term="%22Wang+LL%22">Wang LL</searchLink>; Psychiatric Department 8, Tianjin Anding Hospital, Tianjin, 300222, China.<br /><searchLink fieldCode="AU" term="%22Zhou+JC%22">Zhou JC</searchLink>; The 11th People's Hospital of Chongqing, Chongqing, 400030, China.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Psychosomatic Medicine Department, Deyang People's Hospital, Deyang, Sichuan, 618000, China.<br /><searchLink fieldCode="AU" term="%22Fan+LL%22">Fan LL</searchLink>; Drug Clinical Trial Institution, Deyang People's Hospital, Deyang, Sichuan, 618000, China.<br /><searchLink fieldCode="AU" term="%22Sun+JS%22">Sun JS</searchLink>; Premium Psychiatric Services Department, The Third People's Hospital of Huzhou, Huzhou, Zhejiang, 313000, China.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Zhuhai Livzon Microsphere Technology Co., Ltd., Livzon Pharmaceutical Group Inc., Zhuhai, Guangdong, 519090, China.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital Affiliated to Capital Medical University, Beijing, 100088, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Xi'an+Jiaotong+University%22">Xi'an Jiaotong University </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101579451 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2214-0883 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222140883%22">22140883 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Anal <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.jpha.2025.101350
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        StartPage: 101350
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              Text: 2026 Jan
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