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Class II Peptide-Major Histocompatibility Complex Lipid Nanoparticles Enable in vivo mRNA Delivery to Antigen-Specific CD4+ T Cells.

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Title: Class II Peptide-Major Histocompatibility Complex Lipid Nanoparticles Enable in vivo mRNA Delivery to Antigen-Specific CD4+ T Cells.
Authors: Choy J; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Cheng L; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Patel M; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Zhu Y; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Ma J; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Kang SS; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Jain M; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Biggs BA; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Schneck JP; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Mao HQ; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2026 Feb 11; Vol. 18 (5), pp. 7818-7829. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
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  Data: Class II Peptide-Major Histocompatibility Complex Lipid Nanoparticles Enable in vivo mRNA Delivery to Antigen-Specific CD4<superscript>+</superscript> T Cells.
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  Data: <searchLink fieldCode="AU" term="%22Choy+J%22">Choy J</searchLink>; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Cheng+L%22">Cheng L</searchLink>; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Patel+M%22">Patel M</searchLink>; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Kang+SS%22">Kang SS</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Jain+M%22">Jain M</searchLink>; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Biggs+BA%22">Biggs BA</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Schneck+JP%22">Schneck JP</searchLink>; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.<br /><searchLink fieldCode="AU" term="%22Mao+HQ%22">Mao HQ</searchLink>; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
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  Data: <searchLink fieldCode="JN" term="%22101504991%22">ACS applied materials & interfaces</searchLink> [ACS Appl Mater Interfaces] 2026 Feb 11; Vol. 18 (5), pp. 7818-7829. <i>Date of Electronic Publication: </i>2026 Feb 02.
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        Value: 10.1021/acsami.5c21115
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      – TitleFull: Class II Peptide-Major Histocompatibility Complex Lipid Nanoparticles Enable in vivo mRNA Delivery to Antigen-Specific CD4+ T Cells.
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              Text: 2026 Feb 11
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