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Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson's disease.

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Title: Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson's disease.
Authors: De-Paula RB; Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX 77030, USA., Kim J; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Rhinn H; Leal Therapeutics, Worcester, MA, USA., Saade H; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Chavez F; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Segura T; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Lozano MV; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Etoundi M; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Silos K; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Kass N; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Korchina V; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Venner E; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Masdeu JC; Nantz National Alzheimer Center, Houston Methodist Neurological Institute and Weill Cornell Medicine, Houston, TX 77030, USA., Pavlik V; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Yu MM; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Lin CR; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Jankovic J; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA., Muzny D; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Elsea SH; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Abeliovich A; Leal Therapeutics, Worcester, MA, USA., Lansbury P; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA., Vanegas-Arroyave N; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Baylor College of Medicine, Houston, TX 77030, USA., Shaw CA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Baylor College of Medicine, Houston, TX 77030, USA., Shulman JM; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Source: Brain : a journal of neurology [Brain] 2026 Feb 02. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22De-Paula+RB%22">De-Paula RB</searchLink>; Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Rhinn+H%22">Rhinn H</searchLink>; Leal Therapeutics, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saade+H%22">Saade H</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chavez+F%22">Chavez F</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Segura+T%22">Segura T</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lozano+MV%22">Lozano MV</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Etoundi+M%22">Etoundi M</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Silos+K%22">Silos K</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kass+N%22">Kass N</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Korchina+V%22">Korchina V</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Doddapaneni+H%22">Doddapaneni H</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Venner+E%22">Venner E</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Masdeu+JC%22">Masdeu JC</searchLink>; Nantz National Alzheimer Center, Houston Methodist Neurological Institute and Weill Cornell Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Pavlik+V%22">Pavlik V</searchLink>; 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Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Elsea+SH%22">Elsea SH</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Abeliovich+A%22">Abeliovich A</searchLink>; Leal Therapeutics, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lansbury+P%22">Lansbury P</searchLink>; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Vanegas-Arroyave+N%22">Vanegas-Arroyave N</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+CA%22">Shaw CA</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Shulman+JM%22">Shulman JM</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
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