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The novel mineralocorticoid receptor modulator balcinrenone protects against diet-induced cardiac microvascular dysfunction and plasma potassium elevation in mouse models.

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Title: The novel mineralocorticoid receptor modulator balcinrenone protects against diet-induced cardiac microvascular dysfunction and plasma potassium elevation in mouse models.
Authors: Wolf MJ; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America., El Moghrabi S; INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France., Palacios-Ramirez R; INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France., Bamberg K; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Bradley LA; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America., Epstein FH; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America., Hartleib-Geschwindner J; Late Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Jaisser F; INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.; Université de Lorraine, INSERM Centre d'Investigations Cliniques-Plurithématique 1433, UMR 1116, CHRU de Nancy, French-Clinical Research, Infrastructure Network (F-CRIN) INI-CRCT, Nancy, France.
Source: PloS one [PLoS One] 2026 Feb 02; Vol. 21 (2), pp. e0341078. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The novel mineralocorticoid receptor modulator balcinrenone protects against diet-induced cardiac microvascular dysfunction and plasma potassium elevation in mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Wolf+MJ%22">Wolf MJ</searchLink>; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22El+Moghrabi+S%22">El Moghrabi S</searchLink>; INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Palacios-Ramirez+R%22">Palacios-Ramirez R</searchLink>; INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bamberg+K%22">Bamberg K</searchLink>; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Bradley+LA%22">Bradley LA</searchLink>; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Epstein+FH%22">Epstein FH</searchLink>; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Hartleib-Geschwindner+J%22">Hartleib-Geschwindner J</searchLink>; Late Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Jaisser+F%22">Jaisser F</searchLink>; INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.; Université de Lorraine, INSERM Centre d'Investigations Cliniques-Plurithématique 1433, UMR 1116, CHRU de Nancy, French-Clinical Research, Infrastructure Network (F-CRIN) INI-CRCT, Nancy, France.
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