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Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial.

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Title: Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial.
Authors: Ostendorf L; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Division of Rheumatology, Inflammation, Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zernicke J; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Klotsche J; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany., Kempkens R; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany., Beenken AE; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Biesen R; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Cheng Q; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Khodadadi L; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Guerra GM; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany., Heinrich F; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany., Durek P; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany., Burmester GR; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Krönke G; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Hiepe F; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Mashreghi MF; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), Berlin, Germany., Alexander T; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany. tobias.alexander@charite.de.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. tobias.alexander@charite.de.
Source: Nature communications [Nat Commun] 2026 Feb 03; Vol. 17 (1), pp. 1312. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Ostendorf+L%22">Ostendorf L</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Division of Rheumatology, Inflammation, Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zernicke+J%22">Zernicke J</searchLink>; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Klotsche+J%22">Klotsche J</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kempkens+R%22">Kempkens R</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Beenken+AE%22">Beenken AE</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Biesen+R%22">Biesen R</searchLink>; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Cheng+Q%22">Cheng Q</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Khodadadi+L%22">Khodadadi L</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Guerra+GM%22">Guerra GM</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Heinrich+F%22">Heinrich F</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Durek+P%22">Durek P</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Burmester+GR%22">Burmester GR</searchLink>; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Krönke+G%22">Krönke G</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hiepe+F%22">Hiepe F</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mashreghi+MF%22">Mashreghi MF</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Alexander+T%22">Alexander T</searchLink>; German Rheumatology Research Centre (DRFZ), an Institute of the Leibniz Association, Berlin, Germany. tobias.alexander@charite.de.; Department of Rheumatology and Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. tobias.alexander@charite.de.
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