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RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia.

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Title: RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia.
Authors: Chen TQ; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Sun YM; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Zhu SX; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Chen XT; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Pu KJ; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Huang HJ; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Pan Q; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Lian JY; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Huang W; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Fang K; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China., Luo XQ; Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, China., Huang LB; Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, China. huanglb3@mail.sysu.edu.cn., Chen YQ; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China. lsscyq@mail.sysu.edu.cn., Wang WT; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China. wangwt8@mail.sysu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 Mar; Vol. 45 (5), pp. 1672-1696. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RBM15B recognizes H3K79me2 to guide selective m<superscript>6</superscript>A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Chen+TQ%22">Chen TQ</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+YM%22">Sun YM</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+SX%22">Zhu SX</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+XT%22">Chen XT</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Pu+KJ%22">Pu KJ</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+HJ%22">Huang HJ</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lian+JY%22">Lian JY</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Fang+K%22">Fang K</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Luo+XQ%22">Luo XQ</searchLink>; Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+LB%22">Huang LB</searchLink>; Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, China. huanglb3@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+YQ%22">Chen YQ</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China. lsscyq@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+WT%22">Wang WT</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China. wangwt8@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Mar; Vol. 45 (5), pp. 1672-1696. <i>Date of Electronic Publication: </i>2026 Feb 02.
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        Value: 10.1038/s44318-026-00707-1
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      – TitleFull: RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia.
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