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Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy.

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Title: Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy.
Authors: Baurès M; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France., Vieira Aleixo AS; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France., Pacreau E; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France., Koshy A; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France., Friedrich V; Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104 - UMR-S 1258, F-67400, Illkirch, France., Diedisheim M; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, IMMEDIAB, F-75015, Paris, France.; Clinique Saint Gatien Alliance (NCT+), Saint-Cyr-sur-Loire, France., Raigel M; Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Hua Y; Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany.; University Duisburg-Essen, Essen, Germany., Dariane C; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.; Université Paris-Cité, Department of Urology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France., Boutillon F; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.; ARCHE Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Université de Rennes, F-35000, Rennes, France., Kenner L; Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.; Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria.; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Christian Doppler Laboratory for Applied Metabolomics, Medical University Vienna, Vienna, Austria.; Center for Biomarker Research in Medicine (CBmed), Graz, Styria, Austria., Marine JC; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Laverny G; Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104 - UMR-S 1258, F-67400, Illkirch, France., Metzger D; Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104 - UMR-S 1258, F-67400, Illkirch, France., Rambow F; Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany. Florian.Rambow@uk-essen.de.; University Duisburg-Essen, Essen, Germany. Florian.Rambow@uk-essen.de., Guidotti JE; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France., Goffin V; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France. Vincent.goffin@inserm.fr.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Mar; Vol. 18 (3), pp. 943-978. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy.
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  Data: <searchLink fieldCode="AU" term="%22Baurès+M%22">Baurès M</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vieira+Aleixo+AS%22">Vieira Aleixo AS</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pacreau+E%22">Pacreau E</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Koshy+A%22">Koshy A</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Friedrich+V%22">Friedrich V</searchLink>; Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104 - UMR-S 1258, F-67400, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Diedisheim+M%22">Diedisheim M</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, IMMEDIAB, F-75015, Paris, France.; Clinique Saint Gatien Alliance (NCT+), Saint-Cyr-sur-Loire, France.<br /><searchLink fieldCode="AU" term="%22Raigel+M%22">Raigel M</searchLink>; Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hua+Y%22">Hua Y</searchLink>; Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany.; University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Dariane+C%22">Dariane C</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.; Université Paris-Cité, Department of Urology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Boutillon+F%22">Boutillon F</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.; ARCHE Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Université de Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Kenner+L%22">Kenner L</searchLink>; Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.; Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria.; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Christian Doppler Laboratory for Applied Metabolomics, Medical University Vienna, Vienna, Austria.; Center for Biomarker Research in Medicine (CBmed), Graz, Styria, Austria.<br /><searchLink fieldCode="AU" term="%22Marine+JC%22">Marine JC</searchLink>; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Laverny+G%22">Laverny G</searchLink>; Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104 - UMR-S 1258, F-67400, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Metzger+D%22">Metzger D</searchLink>; Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104 - UMR-S 1258, F-67400, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Rambow+F%22">Rambow F</searchLink>; Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany. Florian.Rambow@uk-essen.de.; University Duisburg-Essen, Essen, Germany. Florian.Rambow@uk-essen.de.<br /><searchLink fieldCode="AU" term="%22Guidotti+JE%22">Guidotti JE</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Goffin+V%22">Goffin V</searchLink>; Université Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, PRL/GH Pathophysiology, F-75015, Paris, France. Vincent.goffin@inserm.fr.
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