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Improved polygenic risk prediction models for breast cancer subtypes in women of African ancestry.

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Title: Improved polygenic risk prediction models for breast cancer subtypes in women of African ancestry.
Authors: Li JL; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA., Zhang H; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Wang X; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Rockville, MD, USA., Jia G; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., McClellan JC; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Guo W; Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA., Sun Y; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Fiorica PN; Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Ambs S; Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Barnard ME; Slone Epidemiology Center, Boston University, Boston, MA, USA., Chen Y; Department of Population Health, Division of Epidemiology, NYU Grossman School of Medicine, New York, NY, USA., Garcia-Closas M; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Gu J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hu JJ; Department of Public Health Sciences, University of Miami School of Medicine, Miami, FL, USA., John EM; Department of Epidemiology and Population Health and Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Nathanson KL; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Basser Center for BRCA, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Pal T; Department of Medicine, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Shu XO; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Press MF; Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA., Sandler DP; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Troester MA; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Yao S; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Long J; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Ahearn TU; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Brewster AM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Falusi A; Genetic and Bioethics Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Kraft P; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hennis AJM; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.; George Alleyne Chronic Disease Research Centre, University of the West Indies, Bridgetown, Barbados., Makumbi T; Department of Surgery, Mulago Hospital, Kampala, Uganda., Mapoko BSE; Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde, Yaounde Central Hospital, Yaounde, Cameroon., O'Brien KM; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Ojengbede O; Center for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria., Olshan AF; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Reid S; Department of Medicine, Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zirpoli G; Slone Epidemiology Center, Boston University, Boston, MA, USA., Cai Q; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Butler EN; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Huang M; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Obafunwa J; Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Weinberg CR; Biostatistics and Computational Biology Branch, National Institutes of Environmental Health Sciences, Research Triangle Park, NC, USA., Ambrosone C; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Ping J; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Li B; Department of Molecular Physiology and Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Guo X; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Gao G; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Conti DV; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Chatterjee N; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA., Palmer JR; Slone Epidemiology Center, Boston University, Boston, MA, USA., Olopade OI; Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, IL, USA., Zheng W; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Haiman CA; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Huo D; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@bsd.uchicago.edu.
Source: Nature genetics [Nat Genet] 2026 Mar; Vol. 58 (3), pp. 560-569. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 58
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1