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PI3K Inhibition in Combination with Tamoxifen in Patients with Metastatic HR+/HER2- Breast Cancer: Clinical and Circulating Tumor DNA Results.

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Title: PI3K Inhibition in Combination with Tamoxifen in Patients with Metastatic HR+/HER2- Breast Cancer: Clinical and Circulating Tumor DNA Results.
Authors: Voorthuis RAB; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Oliveira M; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., van Rossum AGJ; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., de Boo LW; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Mandjes IAM; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Saura C; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., Muñoz S; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., López García D; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., Schrier M; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Sikorska K; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Lopez-Yurda M; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Schot M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Westphal T; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Korse CM; Clinical Laboratory of the Netherlands Cancer Institute, Amsterdam, the Netherlands., Anand S; Cancer Molecular Diagnostics Laboratory, CRUK Cambridge Cancer Centre, Cambridge, United Kingdom., Bernards R; Divisions of Diagnostic Oncology, Radiotherapy and Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Gallaher WM; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, St. Vincent's-UCD Cancer Centre, University College Dublin, Dublin, Ireland., Beelen K; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Caldas C; Cancer Research UK Cambridge Centre , Cambridge, United Kingdom., Cortes J; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.; Department of Medical Oncology, Ramon y Cajal University Hospital, Madrid, Spain., Linn SC; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Baird RD; Cancer Research UK Cambridge Centre , Cambridge, United Kingdom.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 May 15; Vol. 32 (10), pp. 1983-1994.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PI3K Inhibition in Combination with Tamoxifen in Patients with Metastatic HR+/HER2- Breast Cancer: Clinical and Circulating Tumor DNA Results.
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  Data: <searchLink fieldCode="AU" term="%22Voorthuis+RAB%22">Voorthuis RAB</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Oliveira+M%22">Oliveira M</searchLink>; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22van+Rossum+AGJ%22">van Rossum AGJ</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Boo+LW%22">de Boo LW</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mandjes+IAM%22">Mandjes IAM</searchLink>; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Saura+C%22">Saura C</searchLink>; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz+S%22">Muñoz S</searchLink>; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22López+García+D%22">López García D</searchLink>; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Schrier+M%22">Schrier M</searchLink>; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sikorska+K%22">Sikorska K</searchLink>; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lopez-Yurda+M%22">Lopez-Yurda M</searchLink>; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schot+M%22">Schot M</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Westphal+T%22">Westphal T</searchLink>; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Korse+CM%22">Korse CM</searchLink>; Clinical Laboratory of the Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Anand+S%22">Anand S</searchLink>; Cancer Molecular Diagnostics Laboratory, CRUK Cambridge Cancer Centre, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bernards+R%22">Bernards R</searchLink>; Divisions of Diagnostic Oncology, Radiotherapy and Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gallaher+WM%22">Gallaher WM</searchLink>; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, St. Vincent's-UCD Cancer Centre, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Beelen+K%22">Beelen K</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Caldas+C%22">Caldas C</searchLink>; Cancer Research UK Cambridge Centre , Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cortes+J%22">Cortes J</searchLink>; Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.; Department of Medical Oncology, Ramon y Cajal University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Linn+SC%22">Linn SC</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Baird+RD%22">Baird RD</searchLink>; Cancer Research UK Cambridge Centre , Cambridge, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2026 May 15; Vol. 32 (10), pp. 1983-1994.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1078-0432.CCR-25-2833
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        Text: English
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        StartPage: 1983
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              Text: 2026 May 15
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