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Evaluation of c-Abl inhibitor vodobatinib in subjects with early Parkinson's disease: a phase 2, randomized, double-blind, placebo-controlled study.

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Title: Evaluation of c-Abl inhibitor vodobatinib in subjects with early Parkinson's disease: a phase 2, randomized, double-blind, placebo-controlled study.
Authors: Sarva H; Parkinson's Disease & Movement Disorders Institute, Weill Cornell Medicine, New York, NY, USA., Pahwa R; University of Kansas Medical Center, Kansas City, Kansas, USA., Hernandez-Vara J; Neurology Department, Vall D´Hebron University Hospital, Neurodegenerative Diseases Research Group. Vall D´Hebron Research Institute (VHIR), Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain., Goldstein MA; JEM Research Institute, 130 JFK Drive, Atlantis, FL, USA., Borgohain R; Parkinson's Disease and Movement Disorders Research Center, Yashoda Hospital, Hitec City, Hyderabad, India., Factor SA; Emory University School of Medicine, Atlanta, GA, USA., Inamdar S; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Love D; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Hames C; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Fu Y; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Mergel V; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Goldfine A; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Kumar C; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Piccoli SP; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Yao SL; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA., Hurko O; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA. orest.hurko@sparcmail.com.; Tufts University Medical Center, Graduate School of Biomedical Sciences, Boston, MA, USA. orest.hurko@sparcmail.com.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 Feb 03; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Evaluation of c-Abl inhibitor vodobatinib in subjects with early Parkinson's disease: a phase 2, randomized, double-blind, placebo-controlled study.
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  Data: <searchLink fieldCode="AU" term="%22Sarva+H%22">Sarva H</searchLink>; Parkinson's Disease & Movement Disorders Institute, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pahwa+R%22">Pahwa R</searchLink>; University of Kansas Medical Center, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez-Vara+J%22">Hernandez-Vara J</searchLink>; Neurology Department, Vall D´Hebron University Hospital, Neurodegenerative Diseases Research Group. Vall D´Hebron Research Institute (VHIR), Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Goldstein+MA%22">Goldstein MA</searchLink>; JEM Research Institute, 130 JFK Drive, Atlantis, FL, USA.<br /><searchLink fieldCode="AU" term="%22Borgohain+R%22">Borgohain R</searchLink>; Parkinson's Disease and Movement Disorders Research Center, Yashoda Hospital, Hitec City, Hyderabad, India.<br /><searchLink fieldCode="AU" term="%22Factor+SA%22">Factor SA</searchLink>; Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Inamdar+S%22">Inamdar S</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Love+D%22">Love D</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hames+C%22">Hames C</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Mergel+V%22">Mergel V</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Goldfine+A%22">Goldfine A</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+C%22">Kumar C</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Piccoli+SP%22">Piccoli SP</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Yao+SL%22">Yao SL</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hurko+O%22">Hurko O</searchLink>; Sun Pharma Advanced Research Company Ltd, Cranbury, NJ, USA. orest.hurko@sparcmail.com.; Tufts University Medical Center, Graduate School of Biomedical Sciences, Boston, MA, USA. orest.hurko@sparcmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2026 Feb 03; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Feb 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101675390 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2373-8057 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738057%22">23738057 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Parkinsons Dis <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Feb 03
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