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Repeated fentanyl abstinence intensifies opioid withdrawal and induces a proinflammatory state in striatal microglia.

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Title: Repeated fentanyl abstinence intensifies opioid withdrawal and induces a proinflammatory state in striatal microglia.
Authors: Bergkamp DJ; Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA, 98215-7280, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA., Coffey KR; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA., Dawkins AJ; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA.; Department of Neurobiology, Harvard Medical School, Harvard University, Boston, MA, USA., Rice MT; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA., Peden-Asarch AM; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA., Neumaier JF; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA. neumaier@uw.edu.; Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA, 98215-7280, USA. neumaier@uw.edu.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA. neumaier@uw.edu.
Source: Psychopharmacology [Psychopharmacology (Berl)] 2026 Feb 04. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Repeated fentanyl abstinence intensifies opioid withdrawal and induces a proinflammatory state in striatal microglia.
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  Data: <searchLink fieldCode="AU" term="%22Bergkamp+DJ%22">Bergkamp DJ</searchLink>; Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA, 98215-7280, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA.<br /><searchLink fieldCode="AU" term="%22Coffey+KR%22">Coffey KR</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA.<br /><searchLink fieldCode="AU" term="%22Dawkins+AJ%22">Dawkins AJ</searchLink>; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA.; Department of Neurobiology, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rice+MT%22">Rice MT</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA.<br /><searchLink fieldCode="AU" term="%22Peden-Asarch+AM%22">Peden-Asarch AM</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA.<br /><searchLink fieldCode="AU" term="%22Neumaier+JF%22">Neumaier JF</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, Seattle, WA, 98195-6560, USA. neumaier@uw.edu.; Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA, 98215-7280, USA. neumaier@uw.edu.; VA Puget Sound Health Care System, VISN 20 Mental Illness Research, Education and Clinical Center, 1660 S Columbia Way, Seattle, WA, 98108, USA. neumaier@uw.edu.
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        Value: 10.1007/s00213-026-07011-0
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              Text: 2026 Feb 04
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