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The kinase domain of RIPK3 tunes its scaffolding functions.

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Title: The kinase domain of RIPK3 tunes its scaffolding functions.
Authors: Chiou S; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Horne CR; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Patel KM; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Preaudet A; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Rickard JA; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Royal Melbourne Hospital, Parkville, VIC, Australia., Young SN; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Jois A; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; The Royal Children's Hospital, Parkville, VIC, Australia., Garnish SE; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Hempel A; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Hall C; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Hildebrand JM; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Kueh AJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia., Silke J; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Putoczki TL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Hawkins ED; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. hawkins.e@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. hawkins.e@wehi.edu.au., Samson AL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. samson.a@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. samson.a@wehi.edu.au., Murphy JM; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. jamesm@wehi.edu.au.
Source: Cell death and differentiation [Cell Death Differ] 2026 Feb 03. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chiou+S%22">Chiou S</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Horne+CR%22">Horne CR</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Patel+KM%22">Patel KM</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Preaudet+A%22">Preaudet A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rickard+JA%22">Rickard JA</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Royal Melbourne Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Young+SN%22">Young SN</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jois+A%22">Jois A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; The Royal Children's Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Garnish+SE%22">Garnish SE</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hempel+A%22">Hempel A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hall+C%22">Hall C</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hildebrand+JM%22">Hildebrand JM</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kueh+AJ%22">Kueh AJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Silke+J%22">Silke J</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Putoczki+TL%22">Putoczki TL</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hawkins+ED%22">Hawkins ED</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. hawkins.e@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. hawkins.e@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Samson+AL%22">Samson AL</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. samson.a@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. samson.a@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Murphy+JM%22">Murphy JM</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. jamesm@wehi.edu.au.
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        Value: 10.1038/s41418-026-01677-x
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        Text: English
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