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Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

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Title: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Authors: Strom NI; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Verhulst B; Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA., Bacanu SA; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Cheesman R; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway., Purves KL; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gedik H; Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.; Life Sciences, Integrative Life Sciences Doctoral Program, Virginia Commonwealth University, Richmond, VA, USA.; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Mitchell BL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, Queensland University, Brisbane, Queensland, Australia., Kwong AS; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Centre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Faucon AB; Division of Medicine, Human Genetics, Vanderbilt University, Nashville, TN, USA., Singh K; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Medland S; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Colodro-Conde L; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia., Krebs K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel; University Hospital Basel, Basel, Switzerland., Herms S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel; University Hospital Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, Medical Faculty, University Hospital Basel, Basel, Switzerland., Gehlen J; Center for Human Genetics, University of Marburg, Marburg, Germany., Ripke S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Awasthi S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Palviainen T; Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Tasanko EM; Faculty of Medicine, Department of Psychology and Logopedics, SleepWell Research Program, University of Helsinki, Helsinki, Finland., Peterson RE; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA., Adkins DE; School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, UT, USA., Shabalin AA; School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, UT, USA., Adams MJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Iveson MH; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Campbell A; College of Medicine and Veterinary Medicine, Institute of Genetics and Cancer; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Thomas LF; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Winsvold BS; Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Drange OK; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Mental Health, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; NORMENT Centre, University of Oslo, Oslo, Norway.; Centre of Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Psychiatry, Sørlandet Hospital, Kristiansand, Norway., Børte S; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ter Kuile AR; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Department of Clinical, Educational and Health Psychology, University College London, London, UK., Naamanka J; Hector Insitute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Mannheim, Germany.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Nguyen TH; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Meier SM; Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Corfield EC; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Hannigan L; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK., Levey DF; Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.; Psychiatry, Research, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA., Czamara D; Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Weber H; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany., Choi KW; Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Pistis G; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland., Couvy-Duchesne B; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; ARAMIS laboratory, Paris Brain Institute, Paris, France.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Teumer A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Garcia-Argibay M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Lee D; Department of Statistics, Miami University, Oxford, OH, USA., Wang R; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Bjerkeset O; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Faculty of Nursing and Health Science, Nord University, Levanger, Norway., Stordal E; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Psychiatry, Hospital Namsos, Nord-Trøndelag Health Trustt, Namsos, Norway., Bäckman J; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Salum GA; Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Child Psychiatry, National Institute of Developmental Psychiatry, São Paulo, Brazil., Zai CC; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kennedy JL; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Zai G; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Tiwari AK; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany., Kaprio J; Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Kennedy MM; Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand., Boden J; Psychological Medicine, University of Otago, Christchurch, New Zealand., Havdahl A; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway.; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK., Middeldorp CM; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia., Lopes FL; National Institute of Mental Health, Human Genetics Branch, National Institutes of Health, Bethesda, MD, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA., Akula N; National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, MA, USA., McMahon FJ; National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, MA, USA.; Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MA, USA., Binder EB; Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Fehm L; Department of Psychology, Zentrum für Psychotherapie, Humboldt-Universität zu Berlin, Berlin, Germany., Ströhle A; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Castelao E; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland., Tiemeier H; Social and Behavioral Science, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, Netherlands., Stein DJ; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Whiteman D; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Olsen C; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Fuller Z; 23andMe, Sunnyvale, CA, USA., Wang X; 23andMe, Sunnyvale, CA, USA., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Byrne EM; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia., Lewis G; UCL Division of Psychiatry, University College London, London, UK., Timpson NJ; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK., Davis LK; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hickie IB; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Gillespie NA; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Schumacher J; Center for Human Genetics, University of Marburg, Marburg, Germany., Woldbye DP; Department of Neuroscience, Laboratory of Neural Plasticity, University of Copenhagen, Copenhagen, Denmark., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Center for Human Genetics, University of Marburg, Marburg, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Hovatta I; Faculty of Medicine, Department of Psychology and Logopedics and SleepWell Research Program, University of Helsinki, Helsinki, Finland., Horwood J; Psychological Medicine, University of Otago, Christchurch, New Zealand., Copeland WE; UVM Medical Center, Department of Psychiatry, University of Vermont, Burlington, VT, USA., Maes HH; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., McIntosh AM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway.; Centre of Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo, Norway.; K. G. Jebsen Center for Neurodevelopmental disorders, University of Oslo, Oslo, Norway., Zwart JA; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Mors O; Department of Psychiatry, Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark., Børglum AD; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalised Medicine, Aarhus University, Aarhus, Denmark., Mortensen PB; The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark., Ask H; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Reichborn-Kjennerud T; NORMENT Centre, University of Oslo, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Najman JM; Faculty of Medicine, School of Public Health, University of Queensland, Herston, Queensland, Australia., Stein MB; Psychiatry, University of California San Diego, La Jolla, CA, USA.; School of Public Health, University of California San Diego, La Jolla, CA, USA., Gelernter J; Psychiatry, Research, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.; Psychiatry Research, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.; Departments of Genetics and Neuroscience, Yale University of Medicine, New Haven, CT, USA., Milaneschi Y; Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, The Netherlands., Penninx BW; Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, The Netherlands., Boomsma DI; Twin Register and Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, The Netherlands., Maron E; Centre for Digital Health: Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.; Department of Medicine, Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK., Erhardt-Lehmann A; Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Rück C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Kircher TT; Department of Psychiatry, University of Marburg, Marburg, Germany., Melzig CA; Psychology, Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany.; Psychology, Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany., Alpers GW; School of Social Sciences, Department of Psychology, University of Mannheim, Mannheim, Germany., Arolt V; Department of Mental Health, Institute for Translational Psychiatry, University of Muenster, Muenster, Germany., Domschke K; Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin, Berlin, Germany., Smoller JW; Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Preisig M; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland., Martin NG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Lupton MK; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, Queensland University, Brisbane, Queensland, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Luik AI; Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Larsson H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Oldehinkel AJ; Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hartman CA; Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Breen G; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Docherty AR; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; School of Medicine, Psychiatry, University of Utah, Salt Lake City, UT, USA.; School of Medicine, Psychiatry; Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA., Coon H; School of Medicine, Psychiatry, University of Utah, Salt Lake City, UT, USA., Conrad R; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany., Lehto K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany. deckert_j@ukw.de., Eley TC; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. thalia.eley@kcl.ac.uk., Mattheisen M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. manuel.mattheisen@dal.ca.; Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. manuel.mattheisen@dal.ca.; Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada. manuel.mattheisen@dal.ca., Hettema JM; Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA. hettema@tamu.edu.
Corporate Authors: Veterans Affairs Million Veteran Program, FinnGen, 23andMe Research Team
Source: Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 275-288. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Strom+NI%22">Strom NI</searchLink>; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Verhulst+B%22">Verhulst B</searchLink>; Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bacanu+SA%22">Bacanu SA</searchLink>; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Cheesman+R%22">Cheesman R</searchLink>; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Purves+KL%22">Purves KL</searchLink>; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gedik+H%22">Gedik H</searchLink>; Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.; Life Sciences, Integrative Life Sciences Doctoral Program, Virginia Commonwealth University, Richmond, VA, USA.; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+BL%22">Mitchell BL</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, Queensland University, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Kwong+AS%22">Kwong AS</searchLink>; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Centre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Faucon+AB%22">Faucon AB</searchLink>; Division of Medicine, Human Genetics, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Medland+S%22">Medland S</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Colodro-Conde+L%22">Colodro-Conde L</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Krebs+K%22">Krebs K</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Hoffmann+P%22">Hoffmann P</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel; University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Herms+S%22">Herms S</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel; University Hospital Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, Medical Faculty, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gehlen+J%22">Gehlen J</searchLink>; Center for Human Genetics, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ripke+S%22">Ripke S</searchLink>; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Awasthi+S%22">Awasthi S</searchLink>; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Palviainen+T%22">Palviainen T</searchLink>; Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Tasanko+EM%22">Tasanko EM</searchLink>; Faculty of Medicine, Department of Psychology and Logopedics, SleepWell Research Program, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Peterson+RE%22">Peterson RE</searchLink>; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Adkins+DE%22">Adkins DE</searchLink>; School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Shabalin+AA%22">Shabalin AA</searchLink>; School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Adams+MJ%22">Adams MJ</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Iveson+MH%22">Iveson MH</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+A%22">Campbell A</searchLink>; College of Medicine and Veterinary Medicine, Institute of Genetics and Cancer; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+LF%22">Thomas LF</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Winsvold+BS%22">Winsvold BS</searchLink>; Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Drange+OK%22">Drange OK</searchLink>; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Mental Health, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; NORMENT Centre, University of Oslo, Oslo, Norway.; Centre of Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Psychiatry, Sørlandet Hospital, Kristiansand, Norway.<br /><searchLink fieldCode="AU" term="%22Børte+S%22">Børte S</searchLink>; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Ter+Kuile+AR%22">Ter Kuile AR</searchLink>; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Department of Clinical, Educational and Health Psychology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Naamanka+J%22">Naamanka J</searchLink>; Hector Insitute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Mannheim, Germany.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Nguyen+TH%22">Nguyen TH</searchLink>; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Meier+SM%22">Meier SM</searchLink>; Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Corfield+EC%22">Corfield EC</searchLink>; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hannigan+L%22">Hannigan L</searchLink>; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Levey+DF%22">Levey DF</searchLink>; Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.; Psychiatry, Research, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Czamara+D%22">Czamara D</searchLink>; Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+H%22">Weber H</searchLink>; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Choi+KW%22">Choi KW</searchLink>; Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pistis+G%22">Pistis G</searchLink>; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland.<br /><searchLink fieldCode="AU" term="%22Couvy-Duchesne+B%22">Couvy-Duchesne B</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; ARAMIS laboratory, Paris Brain Institute, Paris, France.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Van+der+Auwera+S%22">Van der Auwera S</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Teumer+A%22">Teumer A</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Karlsson+R%22">Karlsson R</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Garcia-Argibay+M%22">Garcia-Argibay M</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Department of Statistics, Miami University, Oxford, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bjerkeset+O%22">Bjerkeset O</searchLink>; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Faculty of Nursing and Health Science, Nord University, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Stordal+E%22">Stordal E</searchLink>; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Psychiatry, Hospital Namsos, Nord-Trøndelag Health Trustt, Namsos, Norway.<br /><searchLink fieldCode="AU" term="%22Bäckman+J%22">Bäckman J</searchLink>; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Salum+GA%22">Salum GA</searchLink>; Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Child Psychiatry, National Institute of Developmental Psychiatry, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Zai+CC%22">Zai CC</searchLink>; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+JL%22">Kennedy JL</searchLink>; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zai+G%22">Zai G</searchLink>; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tiwari+AK%22">Tiwari AK</searchLink>; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Heilmann-Heimbach+S%22">Heilmann-Heimbach S</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+B%22">Schmidt B</searchLink>; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kaprio+J%22">Kaprio J</searchLink>; Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kennedy+MM%22">Kennedy MM</searchLink>; Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Boden+J%22">Boden J</searchLink>; Psychological Medicine, University of Otago, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Havdahl+A%22">Havdahl A</searchLink>; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway.; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Middeldorp+CM%22">Middeldorp CM</searchLink>; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Lopes+FL%22">Lopes FL</searchLink>; National Institute of Mental Health, Human Genetics Branch, National Institutes of Health, Bethesda, MD, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Akula+N%22">Akula N</searchLink>; National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, MA, USA.<br /><searchLink fieldCode="AU" term="%22McMahon+FJ%22">McMahon FJ</searchLink>; National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, MA, USA.; Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MA, USA.<br /><searchLink fieldCode="AU" term="%22Binder+EB%22">Binder EB</searchLink>; Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fehm+L%22">Fehm L</searchLink>; Department of Psychology, Zentrum für Psychotherapie, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ströhle+A%22">Ströhle A</searchLink>; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Castelao+E%22">Castelao E</searchLink>; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tiemeier+H%22">Tiemeier H</searchLink>; Social and Behavioral Science, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Stein+DJ%22">Stein DJ</searchLink>; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Whiteman+D%22">Whiteman D</searchLink>; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Olsen+C%22">Olsen C</searchLink>; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Fuller+Z%22">Fuller Z</searchLink>; 23andMe, Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; 23andMe, Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wray+NR%22">Wray NR</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Byrne+EM%22">Byrne EM</searchLink>; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Lewis+G%22">Lewis G</searchLink>; UCL Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Timpson+NJ%22">Timpson NJ</searchLink>; Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Davis+LK%22">Davis LK</searchLink>; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hickie+IB%22">Hickie IB</searchLink>; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gillespie+NA%22">Gillespie NA</searchLink>; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Milani+L%22">Milani L</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Schumacher+J%22">Schumacher J</searchLink>; Center for Human Genetics, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Woldbye+DP%22">Woldbye DP</searchLink>; Department of Neuroscience, Laboratory of Neural Plasticity, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Forstner+AJ%22">Forstner AJ</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Center for Human Genetics, University of Marburg, Marburg, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hovatta+I%22">Hovatta I</searchLink>; Faculty of Medicine, Department of Psychology and Logopedics and SleepWell Research Program, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Horwood+J%22">Horwood J</searchLink>; Psychological Medicine, University of Otago, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Copeland+WE%22">Copeland WE</searchLink>; UVM Medical Center, Department of Psychiatry, University of Vermont, Burlington, VT, USA.<br /><searchLink fieldCode="AU" term="%22Maes+HH%22">Maes HH</searchLink>; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22McIntosh+AM%22">McIntosh AM</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; NORMENT Centre, University of Oslo, Oslo, Norway.; Centre of Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo, Norway.; K. G. Jebsen Center for Neurodevelopmental disorders, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Zwart+JA%22">Zwart JA</searchLink>; Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Mors+O%22">Mors O</searchLink>; Department of Psychiatry, Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Børglum+AD%22">Børglum AD</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalised Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Mortensen+PB%22">Mortensen PB</searchLink>; The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ask+H%22">Ask H</searchLink>; PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Reichborn-Kjennerud+T%22">Reichborn-Kjennerud T</searchLink>; NORMENT Centre, University of Oslo, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Najman+JM%22">Najman JM</searchLink>; Faculty of Medicine, School of Public Health, University of Queensland, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Stein+MB%22">Stein MB</searchLink>; Psychiatry, University of California San Diego, La Jolla, CA, USA.; School of Public Health, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gelernter+J%22">Gelernter J</searchLink>; Psychiatry, Research, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.; Psychiatry Research, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.; Departments of Genetics and Neuroscience, Yale University of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Milaneschi+Y%22">Milaneschi Y</searchLink>; Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Penninx+BW%22">Penninx BW</searchLink>; Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boomsma+DI%22">Boomsma DI</searchLink>; Twin Register and Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maron+E%22">Maron E</searchLink>; Centre for Digital Health: Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.; Department of Medicine, Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Erhardt-Lehmann+A%22">Erhardt-Lehmann A</searchLink>; Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rück+C%22">Rück C</searchLink>; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kircher+TT%22">Kircher TT</searchLink>; Department of Psychiatry, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Melzig+CA%22">Melzig CA</searchLink>; Psychology, Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany.; Psychology, Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Alpers+GW%22">Alpers GW</searchLink>; School of Social Sciences, Department of Psychology, University of Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Arolt+V%22">Arolt V</searchLink>; Department of Mental Health, Institute for Translational Psychiatry, University of Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Domschke+K%22">Domschke K</searchLink>; Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Preisig+M%22">Preisig M</searchLink>; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland.<br /><searchLink fieldCode="AU" term="%22Martin+NG%22">Martin NG</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Lupton+MK%22">Lupton MK</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, Queensland University, Brisbane, Queensland, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Luik+AI%22">Luik AI</searchLink>; Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Reif+A%22">Reif A</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Grabe+HJ%22">Grabe HJ</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Larsson+H%22">Larsson H</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Magnusson+PK%22">Magnusson PK</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Oldehinkel+AJ%22">Oldehinkel AJ</searchLink>; Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hartman+CA%22">Hartman CA</searchLink>; Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Breen+G%22">Breen G</searchLink>; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Docherty+AR%22">Docherty AR</searchLink>; Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; School of Medicine, Psychiatry, University of Utah, Salt Lake City, UT, USA.; School of Medicine, Psychiatry; Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Coon+H%22">Coon H</searchLink>; School of Medicine, Psychiatry, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Conrad+R%22">Conrad R</searchLink>; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Lehto+K%22">Lehto K</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Deckert+J%22">Deckert J</searchLink>; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany. deckert_j@ukw.de.<br /><searchLink fieldCode="AU" term="%22Eley+TC%22">Eley TC</searchLink>; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. thalia.eley@kcl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Mattheisen+M%22">Mattheisen M</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. manuel.mattheisen@dal.ca.; Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. manuel.mattheisen@dal.ca.; Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada. manuel.mattheisen@dal.ca.<br /><searchLink fieldCode="AU" term="%22Hettema+JM%22">Hettema JM</searchLink>; Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA. hettema@tamu.edu.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 275-288. <i>Date of Electronic Publication: </i>2026 Feb 03.
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      – TitleFull: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
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            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 58
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1