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Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.

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Title: Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.
Authors: Cooper E; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. Elizabeth.Cooper@cruk.cam.ac.uk., Posner DA; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Lee CYC; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Hu L; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Bonner S; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Taylor JT; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Baldwin O; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Jimenez-Guerrero R; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Masih KE; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Rahrmann KW; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Eigenbrood J; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Ngo G; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Franklin VNR; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., D'Santos CS; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Mair R; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Santarius T; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Craven C; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Jalloh I; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Moreno Vicente J; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Halim TYF; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Wang L; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA., Kreigstien AR; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA., Wainwright B; Faculty of Health, Medical and Behavioral Sciences, Frazer Institute, University of Queensland, Brisbane, Queensland, Australia., Swartling FJ; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Khan J; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Clatworthy MR; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Gilbertson RJ; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. Richard.Gilbertson@cruk.cam.ac.uk.; Department of Oncology, Cambridge Biomedical Campus, Cambridge, UK. Richard.Gilbertson@cruk.cam.ac.uk.
Source: Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 317-328. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cooper+E%22">Cooper E</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. Elizabeth.Cooper@cruk.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Posner+DA%22">Posner DA</searchLink>; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lee+CYC%22">Lee CYC</searchLink>; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bonner+S%22">Bonner S</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+JT%22">Taylor JT</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Baldwin+O%22">Baldwin O</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jimenez-Guerrero+R%22">Jimenez-Guerrero R</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Masih+KE%22">Masih KE</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.; Genetics Branch, NCI, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rahrmann+KW%22">Rahrmann KW</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Eigenbrood+J%22">Eigenbrood J</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ngo+G%22">Ngo G</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Franklin+VNR%22">Franklin VNR</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22D'Santos+CS%22">D'Santos CS</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mair+R%22">Mair R</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Santarius+T%22">Santarius T</searchLink>; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Craven+C%22">Craven C</searchLink>; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jalloh+I%22">Jalloh I</searchLink>; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Moreno+Vicente+J%22">Moreno Vicente J</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Halim+TYF%22">Halim TYF</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kreigstien+AR%22">Kreigstien AR</searchLink>; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wainwright+B%22">Wainwright B</searchLink>; Faculty of Health, Medical and Behavioral Sciences, Frazer Institute, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Swartling+FJ%22">Swartling FJ</searchLink>; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Khan+J%22">Khan J</searchLink>; Genetics Branch, NCI, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Clatworthy+MR%22">Clatworthy MR</searchLink>; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gilbertson+RJ%22">Gilbertson RJ</searchLink>; CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. Richard.Gilbertson@cruk.cam.ac.uk.; Department of Oncology, Cambridge Biomedical Campus, Cambridge, UK. Richard.Gilbertson@cruk.cam.ac.uk.
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