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Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope.

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Title: Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope.
Authors: Gieselmann L; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany., DeLaitsch AT; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Rohde M; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Radford C; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., Worczinski J; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Ashurov A; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Ahmadov E; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Burger JA; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands., Havenar-Daughton C; Vir Biotechnology, San Francisco, CA, USA., Deshpande S; Vir Biotechnology, San Francisco, CA, USA., Giovannoni F; Vir Biotechnology, Bellinzona, Switzerland., Corti D; Vir Biotechnology, Bellinzona, Switzerland., Kreer C; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Ercanoglu MS; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Schommers P; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Georgiev IS; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., West AP Jr; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Knüfer J; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Stumpf R; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Kroidl A; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany., Geldmacher C; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany., Maganga L; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania., William W; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania., Ntinginya NE; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania., Hoelscher M; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany., Yang Z; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Wei Q; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., Renfrow MB; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Green TJ; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., Novak J; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands., Gristick HB; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Gruell H; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Bjorkman PJ; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Klein F; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. florian.klein@uk-koeln.de.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany. florian.klein@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. florian.klein@uk-koeln.de.
Source: Nature immunology [Nat Immunol] 2026 Mar; Vol. 27 (3), pp. 572-585. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332<subscript>gp120</subscript> glycan-independent epitope.
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Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stumpf+R%22">Stumpf R</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kroidl+A%22">Kroidl A</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Geldmacher+C%22">Geldmacher C</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Maganga+L%22">Maganga L</searchLink>; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania.<br /><searchLink fieldCode="AU" term="%22William+W%22">William W</searchLink>; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania.<br /><searchLink fieldCode="AU" term="%22Ntinginya+NE%22">Ntinginya NE</searchLink>; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania.<br /><searchLink fieldCode="AU" term="%22Hoelscher+M%22">Hoelscher M</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; 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Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Klein+F%22">Klein F</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. florian.klein@uk-koeln.de.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany. florian.klein@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. florian.klein@uk-koeln.de.
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