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Spatial transcriptomics reveals tumor microenvironment-driven subtypes of invasive lobular carcinoma.

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Title: Spatial transcriptomics reveals tumor microenvironment-driven subtypes of invasive lobular carcinoma.
Authors: Serra M; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Rediti M; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.; IFOM ETS (Istituto Fondazione di Oncologia Molecolare ETS), - The AIRC (Italian Association for Cancer Research) Institute of Molecular Oncology, Milan 20139, Italy., Collet L; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Lifrange F; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.; Department of Pathology, Centre hospitalier universitaire de Liège, Liège 4000, Belgium., Venet D; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Occelli N; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Papagiannis A; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Vincent D; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Rouas G; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Larsimont D; Department of Pathology, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Vikkula M; Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, Brussels 1200, Belgium., Duhoux FP; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc and Institut de Recherche Expérimentale et Clinique (pôle MIRO), Brussels 1200, Belgium., Rothé F; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium., Sotiriou C; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Feb 10; Vol. 123 (6), pp. e2517567123. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Serra+M%22">Serra M</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Rediti+M%22">Rediti M</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.; IFOM ETS (Istituto Fondazione di Oncologia Molecolare ETS), - The AIRC (Italian Association for Cancer Research) Institute of Molecular Oncology, Milan 20139, Italy.<br /><searchLink fieldCode="AU" term="%22Collet+L%22">Collet L</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Lifrange+F%22">Lifrange F</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.; Department of Pathology, Centre hospitalier universitaire de Liège, Liège 4000, Belgium.<br /><searchLink fieldCode="AU" term="%22Venet+D%22">Venet D</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Occelli+N%22">Occelli N</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Papagiannis+A%22">Papagiannis A</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Vincent+D%22">Vincent D</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Rouas+G%22">Rouas G</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Larsimont+D%22">Larsimont D</searchLink>; Department of Pathology, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Vikkula+M%22">Vikkula M</searchLink>; Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, Brussels 1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Duhoux+FP%22">Duhoux FP</searchLink>; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc and Institut de Recherche Expérimentale et Clinique (pôle MIRO), Brussels 1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Rothé+F%22">Rothé F</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.<br /><searchLink fieldCode="AU" term="%22Sotiriou+C%22">Sotiriou C</searchLink>; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels 1070, Belgium.
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