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In vivo functional profiling and structural characterization of the human GLP1R A316T variant.

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Title: In vivo functional profiling and structural characterization of the human GLP1R A316T variant.
Authors: El Eid L; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Manchanda Y; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Austin G; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Deane-Alder K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Rujan RM; Centre for Health and Life Sciences, Coventry University, Coventry, UK., Mariam Z; Centre for Health and Life Sciences, Coventry University, Coventry, UK., Oqua AI; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Belousoff MJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., de la Serna JB; National Heart and Lung Institute, Imperial College London, London, UK., Sloop KW; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Rutter GA; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; CHUM Research Centre, Faculty of Medicine, University of Montreal, Montreal, QC, Canada.; Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; LKC School of Medicine, Nanyang Technological University, Singapore., Montoya A; MRC Laboratory of Medical Sciences, London, UK., Withers DJ; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Millership SJ; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Bouzakri K; Centre Européen d'Étude du Diabète, Strasbourg, France., Jones B; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Reynolds CA; Centre for Health and Life Sciences, Coventry University, Coventry, UK.; School of Life Sciences, University of Essex, Colchester, UK., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Deganutti G; Centre for Health and Life Sciences, Coventry University, Coventry, UK., Tomas A; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Source: Science advances [Sci Adv] 2026 Feb 06; Vol. 12 (6), pp. eadw0899. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22El+Eid+L%22">El Eid L</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Manchanda+Y%22">Manchanda Y</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Austin+G%22">Austin G</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Deane-Alder+K%22">Deane-Alder K</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rujan+RM%22">Rujan RM</searchLink>; Centre for Health and Life Sciences, Coventry University, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Mariam+Z%22">Mariam Z</searchLink>; Centre for Health and Life Sciences, Coventry University, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Oqua+AI%22">Oqua AI</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Belousoff+MJ%22">Belousoff MJ</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22de+la+Serna+JB%22">de la Serna JB</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sloop+KW%22">Sloop KW</searchLink>; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+GA%22">Rutter GA</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; CHUM Research Centre, Faculty of Medicine, University of Montreal, Montreal, QC, Canada.; Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; LKC School of Medicine, Nanyang Technological University, Singapore.<br /><searchLink fieldCode="AU" term="%22Montoya+A%22">Montoya A</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Withers+DJ%22">Withers DJ</searchLink>; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Millership+SJ%22">Millership SJ</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bouzakri+K%22">Bouzakri K</searchLink>; Centre Européen d'Étude du Diabète, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Jones+B%22">Jones B</searchLink>; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Reynolds+CA%22">Reynolds CA</searchLink>; Centre for Health and Life Sciences, Coventry University, Coventry, UK.; School of Life Sciences, University of Essex, Colchester, UK.<br /><searchLink fieldCode="AU" term="%22Sexton+PM%22">Sexton PM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wootten+D%22">Wootten D</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Deganutti+G%22">Deganutti G</searchLink>; Centre for Health and Life Sciences, Coventry University, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Tomas+A%22">Tomas A</searchLink>; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
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