Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt.

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Title: Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt.
Authors: Pellon A; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain., Sadeghi Nasab SD; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Bidkhori G; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Griffiths JS; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Vaga S; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Begum N; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Blagojevic M; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Sigh NK; QIAGEN Aarhus, Aarhus, Denmark., Kotowicz NK; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Uzochukwu I; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Le Guennec A; NMR Facility, Guy's Campus, King's College London, London, UK., Henley-Smith R; King's Health Partners, Head and Neck Cancer Biobank, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Department of Head and Neck Pathology, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Gregson-Williams H; King's Health Partners, Head and Neck Cancer Biobank, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Clasen F; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, London NW11AT, UK., Pryce M; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Karimpour N; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Cook R; Centre for Oral, Clinical and Translational Science, King's College London, London, UK.; Department of Oral Medicine, Floor 22 Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.; Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK., Anguita J; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Richardson JP; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Thavaraj S; Department of Head and Neck Pathology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Centre for Oral, Clinical and Translational Science, King's College London, London, UK., Naglik JR; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Shoaie S; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.; Quantitative Systems Biology, Faculty of Medicine, Biruni University, Istanbul 34015, Turkey., Moyes DL; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Source: Science advances [Sci Adv] 2026 Feb 06; Vol. 12 (6), pp. eaea0405. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.aea0405