View in EDS HTML Full Text PDF Full Text

Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.

Saved in:
Bibliographic Details
Title: Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.
Authors: Zhang H; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Li Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Zhao Y; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., Wang F; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; School of Pharmacy, Xiamen Medical College, Xiamen, Fujian 361023, China., Lin G; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Niu T; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Li H; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Li Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Liu L; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., Liang Y; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., Shen Y; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., Yi Y; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Zhou H; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Lou S; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., Ye Y; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., He Y; Institute of Transfusion Medicine, Blood Center of Zhejiang Province, Hangzhou, Zhejiang 310052, China., Yang R; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Yao R; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Tian C; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Zhou P; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Wu M; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Chen M; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Xu H; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., You J; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Liao Y; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Yang C; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Zhao A; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Chen C; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China., Li L; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Pei S; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China., Yang S; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Source: Science translational medicine [Sci Transl Med] 2026 Feb 04; Vol. 18 (835), pp. eadu3137. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41637525
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; School of Pharmacy, Xiamen Medical College, Xiamen, Fujian 361023, China.<br /><searchLink fieldCode="AU" term="%22Lin+G%22">Lin G</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Niu+T%22">Niu T</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Yi+Y%22">Yi Y</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Lou+S%22">Lou S</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Ye+Y%22">Ye Y</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Institute of Transfusion Medicine, Blood Center of Zhejiang Province, Hangzhou, Zhejiang 310052, China.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Yao+R%22">Yao R</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Tian+C%22">Tian C</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22You+J%22">You J</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Liao+Y%22">Liao Y</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Zhao+A%22">Zhao A</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.<br /><searchLink fieldCode="AU" term="%22Pei+S%22">Pei S</searchLink>; Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Feb 04; Vol. 18 (835), pp. eadu3137. <i>Date of Electronic Publication: </i>2026 Feb 04.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41637525
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/scitranslmed.adu3137
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: eadu3137
    Titles:
      – TitleFull: Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhang H
      – PersonEntity:
          Name:
            NameFull: Li Y
      – PersonEntity:
          Name:
            NameFull: Zhao Y
      – PersonEntity:
          Name:
            NameFull: Wang F
      – PersonEntity:
          Name:
            NameFull: Lin G
      – PersonEntity:
          Name:
            NameFull: Niu T
      – PersonEntity:
          Name:
            NameFull: Li H
      – PersonEntity:
          Name:
            NameFull: Li Y
      – PersonEntity:
          Name:
            NameFull: Liu L
      – PersonEntity:
          Name:
            NameFull: Liang Y
      – PersonEntity:
          Name:
            NameFull: Shen Y
      – PersonEntity:
          Name:
            NameFull: Yi Y
      – PersonEntity:
          Name:
            NameFull: Zhou H
      – PersonEntity:
          Name:
            NameFull: Lou S
      – PersonEntity:
          Name:
            NameFull: Ye Y
      – PersonEntity:
          Name:
            NameFull: He Y
      – PersonEntity:
          Name:
            NameFull: Yang R
      – PersonEntity:
          Name:
            NameFull: Yao R
      – PersonEntity:
          Name:
            NameFull: Tian C
      – PersonEntity:
          Name:
            NameFull: Zhou P
      – PersonEntity:
          Name:
            NameFull: Wu M
      – PersonEntity:
          Name:
            NameFull: Chen M
      – PersonEntity:
          Name:
            NameFull: Xu H
      – PersonEntity:
          Name:
            NameFull: You J
      – PersonEntity:
          Name:
            NameFull: Liao Y
      – PersonEntity:
          Name:
            NameFull: Yang C
      – PersonEntity:
          Name:
            NameFull: Zhao A
      – PersonEntity:
          Name:
            NameFull: Chen C
      – PersonEntity:
          Name:
            NameFull: Li L
      – PersonEntity:
          Name:
            NameFull: Pei S
      – PersonEntity:
          Name:
            NameFull: Yang S
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 04
              M: 02
              Text: 2026 Feb 04
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 835
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1