Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL).
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| Title: | Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL). |
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| Authors: | Rotondo R; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy. Electronic address: rossella.rotondo@uniroma5.it., Russo M; IRCCS San Raffaele Roma, Rome, 00166, Italy., Iacovelli F; Department of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome, 00133, Italy., Calabrese V; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy., de Iure A; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy., Gaglione M; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Leonardi L; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Cocorocchia G; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Stocchi F; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy., Stocchi V; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy., de Pandis MF; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Picconi B; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy. |
| Source: | Redox biology [Redox Biol] 2026 Mar; Vol. 90, pp. 104060. Date of Electronic Publication: 2026 Jan 27. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41637878 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rotondo+R%22">Rotondo R</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy. Electronic address: rossella.rotondo@uniroma5.it.<br /><searchLink fieldCode="AU" term="%22Russo+M%22">Russo M</searchLink>; IRCCS San Raffaele Roma, Rome, 00166, Italy.<br /><searchLink fieldCode="AU" term="%22Iacovelli+F%22">Iacovelli F</searchLink>; Department of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome, 00133, Italy.<br /><searchLink fieldCode="AU" term="%22Calabrese+V%22">Calabrese V</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy.<br /><searchLink fieldCode="AU" term="%22de+Iure+A%22">de Iure A</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy.<br /><searchLink fieldCode="AU" term="%22Gaglione+M%22">Gaglione M</searchLink>; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy.<br /><searchLink fieldCode="AU" term="%22Leonardi+L%22">Leonardi L</searchLink>; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy.<br /><searchLink fieldCode="AU" term="%22Cocorocchia+G%22">Cocorocchia G</searchLink>; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy.<br /><searchLink fieldCode="AU" term="%22Stocchi+F%22">Stocchi F</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy.<br /><searchLink fieldCode="AU" term="%22Stocchi+V%22">Stocchi V</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy.<br /><searchLink fieldCode="AU" term="%22de+Pandis+MF%22">de Pandis MF</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy.<br /><searchLink fieldCode="AU" term="%22Picconi+B%22">Picconi B</searchLink>; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2026 Mar; Vol. 90, pp. 104060. <i>Date of Electronic Publication: </i>2026 Jan 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41637878 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.redox.2026.104060 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 104060 Titles: – TitleFull: Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rotondo R – PersonEntity: Name: NameFull: Russo M – PersonEntity: Name: NameFull: Iacovelli F – PersonEntity: Name: NameFull: Calabrese V – PersonEntity: Name: NameFull: de Iure A – PersonEntity: Name: NameFull: Gaglione M – PersonEntity: Name: NameFull: Leonardi L – PersonEntity: Name: NameFull: Cocorocchia G – PersonEntity: Name: NameFull: Stocchi F – PersonEntity: Name: NameFull: Stocchi V – PersonEntity: Name: NameFull: de Pandis MF – PersonEntity: Name: NameFull: Picconi B IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2213-2317 Numbering: – Type: volume Value: 90 Titles: – TitleFull: Redox biology Type: main |
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