Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL).
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| Title: | Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL). |
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| Authors: | Rotondo R; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy. Electronic address: rossella.rotondo@uniroma5.it., Russo M; IRCCS San Raffaele Roma, Rome, 00166, Italy., Iacovelli F; Department of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome, 00133, Italy., Calabrese V; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy., de Iure A; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy., Gaglione M; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Leonardi L; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Cocorocchia G; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Stocchi F; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy., Stocchi V; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy., de Pandis MF; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Via G. Di Biasio 1, Cassino, 03043, Italy., Picconi B; Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, 00166, Italy; IRCCS San Raffaele Roma, Rome, 00166, Italy. |
| Source: | Redox biology [Redox Biol] 2026 Mar; Vol. 90, pp. 104060. Date of Electronic Publication: 2026 Jan 27. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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