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HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier.

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Title: HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier.
Authors: Overstreet AC; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Burge M; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Anderson B; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Zhu X; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Tao Y; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Cham CM; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Michaud B; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Horam S; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Sangwan N; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Dwidar M; Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Liu X; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Santos A; Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Srivastava V; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Finney C; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Goins CM; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Dai Z; Department of Gastroenterology, Renji Hospital, Shanghai 200127, China., Koff BB; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Stauffer SR; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Leone VA; Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA., Messer JS; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: messerj3@ccf.org.
Source: Cell host & microbe [Cell Host Microbe] 2026 Feb 11; Vol. 34 (2), pp. 230-244.e13. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Overstreet+AC%22">Overstreet AC</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Burge+M%22">Burge M</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+B%22">Anderson B</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Cham+CM%22">Cham CM</searchLink>; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Michaud+B%22">Michaud B</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Horam+S%22">Horam S</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Sangwan+N%22">Sangwan N</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Dwidar+M%22">Dwidar M</searchLink>; Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Santos+A%22">Santos A</searchLink>; Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Srivastava+V%22">Srivastava V</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Finney+C%22">Finney C</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Goins+CM%22">Goins CM</searchLink>; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Dai+Z%22">Dai Z</searchLink>; Department of Gastroenterology, Renji Hospital, Shanghai 200127, China.<br /><searchLink fieldCode="AU" term="%22Koff+BB%22">Koff BB</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Stauffer+SR%22">Stauffer SR</searchLink>; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Leone+VA%22">Leone VA</searchLink>; Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.<br /><searchLink fieldCode="AU" term="%22Messer+JS%22">Messer JS</searchLink>; Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: messerj3@ccf.org.
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  Data: <searchLink fieldCode="JN" term="%22101302316%22">Cell host & microbe</searchLink> [Cell Host Microbe] 2026 Feb 11; Vol. 34 (2), pp. 230-244.e13. <i>Date of Electronic Publication: </i>2026 Feb 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101302316 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1934-6069 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219313128%22">19313128 </searchLink><i>NLM ISO Abbreviation: </i>Cell Host Microbe <i>Subsets: </i>MEDLINE
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