Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells.
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| Title: | Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells. |
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| Authors: | Stavrou V; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Ali M; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Gudgeon N; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Bishop EL; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Fulton-Ward T; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Turley B; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Heising S; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Mohamed SH; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Hain S; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., George L; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Deng M; Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK., McCowan J; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK., Sheriff L; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Davies SP; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK., Marzullo B; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Tennant DA; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Doig CL; Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Bending DA; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK., Roberts EW; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK., Lavery GG; Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Drummond RA; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Dimeloe S; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.k.dimeloe@bham.ac.uk.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.k.dimeloe@bham.ac.uk. |
| Source: | Nature communications [Nat Commun] 2026 Feb 04; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41639086 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4<superscript>+</superscript> T cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Stavrou+V%22">Stavrou V</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Gudgeon+N%22">Gudgeon N</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Bishop+EL%22">Bishop EL</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Fulton-Ward+T%22">Fulton-Ward T</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Turley+B%22">Turley B</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Heising+S%22">Heising S</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Mohamed+SH%22">Mohamed SH</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Hain+S%22">Hain S</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22George+L%22">George L</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Deng+M%22">Deng M</searchLink>; Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22McCowan+J%22">McCowan J</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Sheriff+L%22">Sheriff L</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Davies+SP%22">Davies SP</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Marzullo+B%22">Marzullo B</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Tennant+DA%22">Tennant DA</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Doig+CL%22">Doig CL</searchLink>; Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Bending+DA%22">Bending DA</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+EW%22">Roberts EW</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Lavery+GG%22">Lavery GG</searchLink>; Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Drummond+RA%22">Drummond RA</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Dimeloe+S%22">Dimeloe S</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.k.dimeloe@bham.ac.uk.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.k.dimeloe@bham.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 04; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 04. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41639086 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-68863-w Languages: – Code: eng Text: English Titles: – TitleFull: Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Stavrou V – PersonEntity: Name: NameFull: Ali M – PersonEntity: Name: NameFull: Gudgeon N – PersonEntity: Name: NameFull: Bishop EL – PersonEntity: Name: NameFull: Fulton-Ward T – PersonEntity: Name: NameFull: Turley B – PersonEntity: Name: NameFull: Heising S – PersonEntity: Name: NameFull: Mohamed SH – PersonEntity: Name: NameFull: Hain S – PersonEntity: Name: NameFull: George L – PersonEntity: Name: NameFull: Deng M – PersonEntity: Name: NameFull: McCowan J – PersonEntity: Name: NameFull: Sheriff L – PersonEntity: Name: NameFull: Davies SP – PersonEntity: Name: NameFull: Marzullo B – PersonEntity: Name: NameFull: Tennant DA – PersonEntity: Name: NameFull: Doig CL – PersonEntity: Name: NameFull: Bending DA – PersonEntity: Name: NameFull: Roberts EW – PersonEntity: Name: NameFull: Lavery GG – PersonEntity: Name: NameFull: Drummond RA – PersonEntity: Name: NameFull: Dimeloe S IsPartOfRelationships: – BibEntity: Dates: – D: 04 M: 02 Text: 2026 Feb 04 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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